Gilda H. Loew

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Refined 3D models of the transmembrane domains of the cloned delta, mu and kappa opioid receptors belonging to the superfamily of G-protein coupled receptors (GPCRs) were constructed from a multiple sequence alignment using the alpha carbon template of rhodopsin recently reported. Other key steps in the procedure were relaxation of the 3D helix bundle by(More)
  • C Adolphsen, K Bane, G Loew, R Ruth, K Thompson, J Wang
  • 1992
Research is underway at SLAC to develop accelerator structures for the next generation linear collider. An important feature of the design is a detuning of the dipole moddes-of the cells to suppress the long-range transverse wakefield bptwo orders of magnitude. This paper describes a facility, called ASSET, that will be incorporated into the SLAC Linear(More)
Like benzodiazepines receptor (BDZR) ligands, 3 alpha-hydroxylated, 5 alpha, or 5 beta pregnane steroids are sedative, anticonvulsant, and anxiolytic. BDZR ligands also modulate the feeding response. Therefore, in this study we have investigated the effects of four 3 alpha-hydroxylated pregnane steroids-Pregnanolone (3 alpha-hydroxy-5 beta-pregnan-20-one),(More)
Computer-assisted analysis of competitive binding studies of [3H]-naloxone, [3H]-DADL, morphine and meperidine in the presence and absence of 100 mM NaCl have been made. The results are most consistent with a 3-site model of opiate receptors and indicate that in the presence of Na+ naloxone changes from a mu-specific (81%) to a more kappa-specific (63%)(More)
To explore behavioral selectivity as a consequence of multiple receptor subtypes, four benzodiazepine receptor ligands, flunitrazepam, CGS 9896, zolpidem, and AHR 11797, were tested at five in vivo endpoints: anticonvulsant action, anxiolysis/anxiogenesis as determined in the plus-maze test, locomotor activity, changes in food consumption, and hypothermia.(More)
The goals of the present work were to characterize the binding profile of nine benzodiazepine ligands in Spodotera frugiperda (Sf-9) insect cells expressing specific gamma aminobutyric acid (A) (GABA(A)) receptor subunit combinations and compare the affinities to those for the receptors in the rat cerebellum. Three recombinant baculovirus constructs, each(More)
In this minireview an overview description of the different pharmacophores that have been proposed for the benzodiazepine receptor is presented. The methodology as well as the experimental information used in the development of each model will be described. Finally, the new experimental discoveries that are likely to affect the models presented are briefly(More)
  • H Win, K Bane, R Boyce, J Cobb, G Loew, P Morton +19 others
  • 1993
Recent techr.tologicaJ developments have opened the possibility to construct a device which we call a knac Coherent Light Source (LCLS)[l4]; a fourth generation light source, with brightness, coherence, and peak power far exceeding other sources. Gperating on the principle of the free electron laser (FEL), the LCLS would extend the range of FEL operation to(More)
Eight compounds that bind to the benzodiazepine binding site on the gamma-amino butyric acid(A) (GABA(A)) receptor were assessed for their influence on contextual memory, an aspect of memory affected in various cognitive disorders including Alzheimer's disease. Using a Pavlovian fear-conditioning paradigm, each ligand was evaluated in C57Bl/6 mice in(More)
  • R Tatchyn, J Arthur, M Baltay, K Bane, R Boyce, M Cornacchia +27 others
  • 1995
In recent years significant studies have been initiated on the feasibility of utilizing a portion of the 3km S-band accelerator at SLAC to drive a short wavelength (4.5-1.5 Å) Linac Coherent Light Source (LCLS), a Free-Electron Laser (FEL) operating in the Self-Amplified Spontaneous Emission (SASE) regime. Electron beam requirements for single-pass(More)