Gilberto López-Pérez

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The use of multilayer perceptrons (MLP) feedforward neural networks trained by back-propagation (BP) for non-linear QSAR model building is presented and explained in detail through a case study. This method was compared with others often used in this field, such as multiple linear regression (MLR), partial least squares (PLS) and quadratic PLS (QPLS). The(More)
In this work, the synthesis of 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carbonitrile (C9) and the study of its biological activity as a new putative antagonist of vasopressin receptors are described. The chemical identification of the compound C9 was confirmed using 1H and 13C nuclear magnetic resonance. This compound(More)
INTRODUCTION Fragile X syndrome, which is produced by mutation of a gene in the X chromosome, is the most frequent cause of hereditary mental retardation. The multisystemic alterations of the disorder are due to the inhibition of the expression of the FMR1 gene and to the lack or absence of FMRP protein. Mental retardation and autistic spectrum constitute(More)
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