Gilberto Castañeda Hernández

Learn More
Biopharmaceuticals have the potential to raise an immunogenic response in treated individuals, which may impact the efficacy and safety profile of these drugs. As a result, it is essential to evaluate immunogenicity throughout the different phases of the clinical development of a biopharmaceutical, including post-marketing surveillance. Although rigorous(More)
The effects and pharmacokinetic parameters of two oral formulations of nifedipine, 10 mg capsule (Adaltat) and 20 mg slow release tablet (Adalat a.p.). With the 10 mg capsule nifedipine was rapidly absorbed, reaching a maximum concentration of 120 +/- 39 ng/ml in 0.52 +/- 0.07 h, and also rapidly eliminated with an apparent halflife of 5.51 +/- 0.64 h. A(More)
The purpose of this work is to study the presence of an endogenous inhibitor of the sodium pump in mammals. A water extract was prepared from guinea pig heart and partially purified by liquid chromatography. The extract inhibited the activity of Na,K-ATPase but had no effect on Mg-ATPase nor on Ca-ATPase. The inhibition was similar to that produced by(More)
Pelanserin pharmacokinetics were studied in six normotensive dogs after intravenous and oral administration. Additionally, the relationship between pelanserin plasma levels and its antihypertensive effect was studied in six hypertensive dogs after a single oral administration. Plasma level-time curves were fitted to an open two compartments model.(More)
In this work we continue the studies on the presence of an endogenous digitalis-like factor in mammals. A water extract from guinea pig heart was partially purified by liquid chromatography. The extract displaced (3H)ouabain specific binding to guinea pig heart Na,K-ATPase yielding a displacement curve parallel to that observed when digoxin was used as(More)
  • 1