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Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
Treatment failure and CNS side-effects are associated with low and high efavirenz plasma levels, respectively, which strongly argues for dose adjustment on the basis of therapeutic drug monitoring to optimize treatment. Expand
Microorganisms Resistant to Free-Living Amoebae
Free-living amoebae represent an important reservoir of ARB and may, while encysted, protect the internalized bacteria from chlorine and other biocides, and represent a useful tool for the culture of some intracellular bacteria and new bacterial species that might be potential emerging pathogens. Expand
Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study
Hematitis C virus and active intravenous drug use could be important factors in the morbidity and mortality among HIV-1-infected patients, possibly through impaired CD4-cell recovery in HCV seropositive patients receiving potent antiretroviral therapy. Expand
Performance of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Bacterial Strains Routinely Isolated in a Clinical Microbiology Laboratory
ABSTRACT Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has recently been introduced in diagnostic microbiology laboratories for the identification ofExpand
Biodiversity of Amoebae and Amoeba-Resisting Bacteria in a Hospital Water Network
The observed strong association between the existence of amoebae and the presence of Legionella and mycobacteria further suggests that FLA are a reservoir for these ARB and underlines the importance of considering amoEBae when water control measures are designed. Expand
Gene Sequence-Based Criteria for Identification of New Rickettsia Isolates and Description of Rickettsia heilongjiangensis sp. nov
ABSTRACT We propose genetic guidelines for the classification of rickettsial isolates at the genus, group, and species levels by using sequences of the 16S rRNA (rrs) gene and four protein-codingExpand
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling
An analysis of a whole genome assembly of Acanthamoeba castellanii, the first representative from a solitary free-living amoebozoan, highlights the important role of LGT in the biology of Ac and in the diversification of microbial eukaryotes. Expand
Biodiversity of amoebae and amoebae-resisting bacteria in a drinking water treatment plant.
As amoebae mainly multiply in sand and GAC filters, optimization of filter backwash procedures probably offers a possibility to better control these protists and the risk associated with their intracellular hosts. Expand
Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology.
MALDI-TOF MS has been used successfully for microbial typing and identification at the subspecies level, demonstrating that this technology is a potential efficient tool for epidemiological studies and for taxonomical classification. Expand
Pathogenic Potential of Novel Chlamydiae and Diagnostic Approaches to Infections Due to These Obligate Intracellular Bacteria
The data supporting a pathogenic potential of the novel chlamydiae for humans and other vertebrates and the interactions that most of these chlam Lydiae have with free-living amoebae are summarized. Expand