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PURPOSE To improve the calculation of T1 relaxation time from a set of variable flip-angle (FA) spoiled gradient recalled echo images. MATERIALS AND METHODS The proposed method: (a) uses a uniform weighting of all FAs, (b) takes into account global inaccuracies in the generation of the prescribed FAs by estimating the actual FAs, and (c) incorporates(More)
We consider the following problem: given a k-(node) connected graph G find a smallest set F of new edges so that the graph G + F is (k + 1)-connected. The complexity status of this problem is an open question. The problem admits a 2-approximation algorithm. Another algorithm due to Jordán computes an augmenting edge set with at most (k − 1)/2 edges over the(More)
This study proposes an automatic method for identification and quantification of different tissue components: the non-enhanced infiltrative tumor, vasogenic edema and enhanced tumor areas, at the subject level, in patients with glioblastoma (GB) based on dynamic contrast enhancement (DCE) and dynamic susceptibility contrast (DSC) MRI. Nineteen MR data sets,(More)
BACKGROUND Current methods for evaluation of treatment response in glioblastoma are inaccurate, limited and time-consuming. This study aimed to develop a multi-modal MRI automatic classification method to improve accuracy and efficiency of treatment response assessment in patients with recurrent glioblastoma (GB). MATERIALS AND METHODS A modification of(More)
BACKGROUND Treatment with bevacizumab is associated with substantial radiologic response in patients with glioblastoma (GB). However, following this initial response, changes in T2-weighted MRI signal may develop, suggesting an infiltrative pattern of tumor progression. The aim of this study was to differentiate between vasogenic-edema versus(More)
Normal brain cells depend on glucose metabolism, yet they have the flexibility to switch to the usage of ketone bodies during caloric restriction. In contrast, tumor cells lack genomic and metabolic flexibility and are largely dependent on glucose. Ketogenic-diet (KD) was suggested as a therapeutic option for malignant brain cancer. This study aimed to(More)
AFFINITY MATURATION OCCURS THROUGH TWO SELECTION PROCESSES the choice of appropriate clones (clonal selection), and the internal evolution within clones, induced by somatic hyper-mutations, where high affinity mutants are selected for. When a final population of immunoglobulin sequences is observed, the genetic composition of this population is affected by(More)
Differentiation between treatment-related changes and progressive disease (PD) remains a major clinical challenge in the follow-up of patients with high grade brain tumors. The aim of this study was to differentiate between treatment-related changes and PD using dynamic contrast enhanced (DCE) MRI. Twenty patients were scanned using conventional, DCE-MRI(More)
Compartmental modeling is a widely used tool in neurophysiology but the detail and scope of such models is frequently limited by lack of computational resources. Here we implement compartmental modeling on low cost Graphical Processing Units (GPUs), which significantly increases simulation speed compared to NEURON. Testing two methods for solving the(More)