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Accumulation of depolarized mitochondria within beta-cells has been associated with oxidative damage and development of diabetes. To determine the source and fate of depolarized mitochondria, individual mitochondria were photolabeled and tracked through fusion and fission. Mitochondria were found to go through frequent cycles of fusion and fission in a(More)
1 OBJECTIVE—Previous studies have reported that ␤-cell mito-chondria exist as discrete organelles that exhibit heterogeneous bioenergetic capacity. To date, networking activity, and its role in mediating ␤-cell mitochondrial morphology and function, remains unclear. In this article, we investigate ␤-cell mitochon-drial fusion and fission in detail and(More)
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