Gil-Sun Hong

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Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during apoptosis cain/cabin1 is cleaved by calpain at the carboxyl terminus to generate a cleavage product with a molecular mass of 32 kDa as a necessary step leading to(More)
Over the last three years, increasing numbers of adaptor molecules that contain the caspase recruitment domain (CARD) have been identified. CARD was originally described as a protein-binding motif that interacts with caspase through a CARD-CARD interaction. However, CARD has now also been found in many adaptor proteins that do not interact with caspase, but(More)
We have identified a novel CARD-containing protein from EST database. BinCARD (Bcl10-interacting protein with CARD). BinCARD was ubiquitously expressed. Co-immunoprecipitation, In vitro binding, mammalian two-hybrid, and immunostaining assays revealed that BinCARD interacted with Bcl10 through CARD. BinCARD potently suppressed NF-kappa B activation induced(More)
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