BACKGROUND
Feeding a high-fructose diet induces hypertension and insulin-resistance in Sprague-Dawley rats.
METHODS
To investigate whether insulin receptors contribute to abnormal glucose… (More)
BACKGROUND
Experimental and human studies demonstrate that long-term exposure to elevated aldosterone levels results in cardiac and vascular damage.
METHODS
We investigated long-term cardiovascular… (More)
Exposure to excess aldosterone results in cardiac damage in hypertensive states. We evaluated the long-term cardiac structural and functional evolution in patients with primary aldosteronism after… (More)
Mineralocorticoid receptor antagonists (MRAs) are commonly used to reduce blood pressure, left-ventricular hypertrophy, and urinary albumin excretion in patients with essential hypertension or… (More)
CONTEXT
The relationship between aldosterone and glucose metabolism is poorly understood, and there is substantial disparity among findings of studies that have examined glucose tolerance and insulin… (More)
Recent evidence indicates a greater frequency of primary aldosteronism (PA) among patients with hypertension than the previously accepted prevalence. PA was once considered a relatively benign form… (More)
BACKGROUND
The renal damage that is present in primary aldosteronism might reflect functional and potentially reversible abnormalities that are initiated by glomerular hyperfiltration. The aim of… (More)
BACKGROUND
Hyperhomocysteinemia and the metabolic syndrome are established cardiovascular risk factors and are frequently associated with hypertension. The relationship of plasma homocysteine (Hcy)… (More)
BACKGROUND
Components of the renin-angiotensin-aldosterone system (RAAS) and a prothrombotic state are predictors of cardiovascular events in hypertensive patients. A relationship between the RAAS… (More)
AIM
A prothrombotic state is associated with organ damage in hypertensive patients. Carotid intima-media thickness (IMT) is an early marker of vascular damage that anticipates the development of… (More)