Gianfranco Catalano

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BACKGROUND The objective of this study was to gain insight into the molecular mechanism of induced cell death (apoptosis) by PYRROLO [1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) series compounds, using human (K562) cells as a model. METHODS We focused our attention on some members of the PBTDs family to test their potential apoptotic activity in K562 cells.(More)
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Therapy-related myeloid neoplasm, usually in the forms of myelodysplastic syndromes/acute myeloid leukemias (t-MDS/AML), are well-known secondary malignancies occurring in cancer patients who received chemo-radiotherapy(More)
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Long-term hematological response in a patient with 5q-syndrome after suspension of lenalidomide therapy and further improvement with deferasirox therapy TO THE EDITOR: Anemia and its related clinical effects, including(More)
Chronic lymphocytic leukemia (CLL) is characterized by extremely variable clinical course indicating substantial differences in the biology of the disease. Molecular characterization provides new insights useful for treatment decision making. We report on a patient diagnosed with CLL, whose disease was characterized by episodes of rapid progression and(More)
228 Letters to the Editor reduction or discontinuation of immunosuppressant agents for restoration of immunity are known to be the best ways to control infection. This report emphasizes the importance of considering the presence of BKV encephalitis in allogeneic SCT recipients on immunosuppressant medications who present with neurological symptoms even(More)
Acute promyelocitic leukemia (APL) is characterized by the pathognomonic presence in leukemic blasts of the hybrid protein PML/RARA, that acts as a transcriptional repressor impairing the expression of genes that are critical to myeloid differentiation. Here, we show that primary blasts from APL patients express lower levels of the oncosuppressor protein(More)
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