Gian Paolo Trentini

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Cyclin D1 contributes to regulate G1 progression by forming a complex with different cyclin-dependent kinases. It has oncogenic properties and is frequently overexpressed in several human tumor types. In our study, expression of cyclin D1 and Ki67, a proliferation marker, was evaluated by immunohistochemistry in human papillary superficial (pTa-pT1) bladder(More)
Dystroglycan (DG) is an adhesion molecule responsible for crucial interactions between extracellular matrix and cytoplasmic compartment. It is formed by two subunits, alpha-DG (extracellular) and beta-DG (transmembrane), that bind to laminin in the matrix and dystrophin in the cytoskeleton, respectively. In this study we evaluated by Western blot analysis(More)
OBJECTIVE To compare the clinicopathological and immunohistochemical findings of superficial papillary transitional cell carcinomas in "young" and "elderly" patients, as the natural history and prognosis of bladder tumours in young patients remains a matter of debate. PATIENTS AND METHODS Tumours from 50 patients with superficial urothelial tumours of the(More)
p27 is a member of the Cip1/Kip1 family of cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene. We previously reported a deregulated expression of p27 in a series of human cancer cell lines and in primary breast and colon cancers. Moreover, p27 has been reported as an important prognostic factor in primary lung, breast, colon, and(More)
After pinealectomy we were able to observe an accumulation of iron pigment in the histiocytes of the cords and of the follicles of the spleen in the rat, parallel with a slight increase in the enzymatic activity of the histiocytes and hypertrophy of the argentophil reticulum. The accumulation of iron and the enzymatic activity can be further increased by(More)
Mutations in microsatellite sequences are a hallmark of neoplastic transformation and have been reported in the majority of human cancers. Conflicting results have been reported on the role of microsatellite alterations in bladder tumorigenesis and it has been suggested that they might be mainly involved in the development of bladder cancers in young(More)
Aortic amyloid deposits were found in 53% of adult subjects (mean age 47.5 years). They appeared to be localized mainly in the mediaintimal border zone and the internal third of the aortic media, and were not usually related to atherosclerotic lesions. The thoracic aorta was more extensively and frequently involved than the abdominal. It was concluded that(More)
Muir-Torre syndrome (MTS) is defined as the association of a sebaceous tumor or keratoacanthoma and an extracutaneous neoplasm, mainly from the gastrointestinal or genitourinary tracts. MTS is related to hereditary non-polyposis colorectal cancer (HNPCC), a syndrome with germline mutations in the mismatch repair (MMR) gene(s), leading to microsatellite(More)