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Migraine is an extremely common disorder. The underlying mechanisms of this chronic illness interspersed with acute symptoms appear to be increasingly complex. An important aspect of migraine heterogeneity is comorbidity with other neurological diseases, cardiovascular disorders, and psychiatric illnesses. Depressive disorders are among the leading causes(More)
Trigeminal neuralgia (TN) has a prevalence of 0.1-0.2 per thousand and an incidence ranging from about 4-5/100,000/year up to 20/100,000/year after age 60. The female-to-male ratio is about 3:2. A review of several case series shows that pain is more predominant on the right side, but the difference is not statistically significant. TN is significantly(More)
OBJECTIVE To compare almotriptan and zolmitriptan in the treatment of acute migraine. METHODS This multicentre, double-blind trial randomized adult migraineurs to almotriptan 12.5 mg (n = 532) or zolmitriptan 2.5 mg (n = 530) for the treatment of a single migraine attack. The primary end point was sustained pain free plus no adverse events (SNAE); other(More)
The mean global prevalence of tension-type headache (TTH) in adult is 42 %. To date, there have been no Italian studies on TTH prevalence in the adult general population. Therefore, we conducted a cross-sectional study, called PACE (PArma CEfalea, or "Headache in Parma"), aimed at detecting the prevalence and clinical features of primary headaches in the(More)
Cluster headache (CH) has also been called "suicide headache" on account of the extremely severe pain that characterizes its attacks. It is indeed well known that CH sufferers exhibit peculiar behaviours during attacks. The purposes of our study were: i) to investigate prospectively prodromes and clinical pain features and behaviour of patients during(More)
Despite many studies, the mechanisms underlying the pathogenesis of pain in cluster headache (CH) still remain obscure. An involvement of substance P (SP) containing neurons of the Gasserian ganglion and/or of the spinal trigeminal nucleus has recently been suggested, e.g., by impairment of inhibitory descending pathways on trigeminal nociceptive neurons.(More)
the last decade, there have been many studies on epidemiology of migraine. These studies have dealt not only with those aspects that are strictly related to the spread of the disease, such as prevalence and incidence rates, but also with other interesting aspects, such as familial occurrence, comorbidity and disability. In this paper, we deal with migraine(More)
  • G C Manzoni
  • 1995
Following a short analysis of leading principles of the classification and diagnostic criteria of headaches of the International Headache Society (IHS) and a brief description of its nosography of primary headaches, some still debated issues are discussed. The IHS classification shows a good inter-observer reliability both at one- and two-digit levels, even(More)
BACKGROUND Prevalence of cluster headache (CH) is estimated at 56 to 69 per 100,000. OBJECTIVE To calculate the CH lifetime prevalence in a sample representative of the Italian general population over age 14 years. METHODS Possible CH cases according to the diagnostic criteria of the 1988 International Headache Society classification were screened from(More)
Psychiatric comorbidity (prevalence and types) was tested in a naturalistic sample of adult patients with pure migraine without aura, and in two control groups of patients, one experiencing pure tension-type headache and the other combined migraine and tension-type headaches. The study population included 374 patients (158, 110 and 106) from nine Italian(More)