Giampiero de Sanctis

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Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain.

Magda Gioia, Giovanni Francesco Fasciglione, +7 authors Massimo Coletta
The Journal of biological chemistry
2002

The cleavage of bovine collagen I by neutrophil collagenase MMP-8 has been followed at pH 7.4, 37 degrees C. The behavior of the whole enzyme molecule (whMMP-8), displaying both the catalytic domain… (More)

ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus.

Daniela Coppola, Stefania Abbruzzetti, +14 authors Cinzia Verde
Molecular bioSystems
2012

The major haemoglobin of the sub-Antarctic fish Eleginops maclovinus was structurally and functionally characterised with the aim to compare molecular environmental adaptations in the O(2)-transport… (More)

Reciprocal Allosteric Modulation of Carbon Monoxide and Warfarin Binding to Ferrous Human Serum Heme-Albumin

A Alessio Bocedi, Giampiero de Sanctis, +8 authors Massimo Coletta
PloS one
2013

Human serum albumin (HSA), the most abundant protein in human plasma, could be considered as a prototypic monomeric allosteric protein, since the ligand-dependent conformational adaptability of HSA… (More)

Functional properties of subunit interactions in human cytidine deaminase.

Silvia Vincenzetti, Giampiero de Sanctis, +7 authors Alberto Vita
Protein engineering
2003

An intersubunit interactions study related to the active site has been performed on the wild-type cytidine deaminase (CDA) and on the mutant enzyme F137W/W113F. F137 is the homologous to the Bacillus… (More)

Proton linkage for CO binding and redox properties of bovine lactoperoxidase.

Chiara Ciaccio, Giampiero de Sanctis, +7 authors Massimo Coletta
Biophysical journal
2004

The pH-dependence of redox properties and of CO binding to bovine lactoperoxidase has been investigated over the range between 2 and 11. The pH-dependence of redox potentials shows a biphasic… (More)

Effect of axial coordination on the kinetics of assembly and folding of the two halves of horse heart cytochrome C.

Giampiero de Sanctis, Chiara Ciaccio, +6 authors Massimo Coletta
The Journal of biological chemistry
2004

The kinetics of the assembly of two complementary fragments of oxidized horse heart cytochrome c (cyt c), namely the heme-containing fragment-(1-56) and the fragment-(57-104), have been characterized… (More)

Cooperativity and allostery in haemoglobin function.

Chiara Ciaccio, Andrea Coletta, Giampiero de Sanctis, Stefano Marini, Massimo Coletta
IUBMB life
2008

Tetrameric haemoglobins display a cooperative ligand binding behaviour, which has been attributed to the functional interrelationship between multiple ligand binding sites. The quantitative… (More)

Incidence of autoimmune thyroiditis in interferon-alpha treated and untreated patients with chronic hepatitis C virus infection.

Alice Di Rocco, S. Gargano, +5 authors Franco Grimaldi
Neuro endocrinology letters
2001

OBJECTIVES To clarify the relationship between interferon-alpha (IFN-alpha) therapy and autoimmune thyroiditis in chronic hepatitis C virus (HCV) infection, we investigated a selected number of… (More)

Structural Bases for the Regulation of CO Binding in the Archaeal Protoglobin from Methanosarcina acetivorans

Lesley Tilleman, Stefania Abbruzzetti, +13 authors Shannon Wing Ngor Au
PloS one
2015

Studies of CO ligand binding revealed that two protein states with different ligand affinities exist in the protoglobin from Methanosarcina acetivorans (in MaPgb*, residue Cys(E20)101 was mutated to… (More)

Prevalence of anti-HCV in two Tanzanian villages.

I Ilardi, Giuseppe Errera, +6 authors Lucia Valeria Chircu
Archives of virology. Supplementum
1992

The presence of anti-HCV antibodies was investigated in sera from a total of 123 inhabitants of two Tanzanian villages. In one of the villages, 72.2% of the sera and in the other village, 82.6% of… (More)

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