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The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.

• Rinke Stienstra, Leo A B Joosten, +17 authors Mihai G Netea
• Cell metabolism
• 2010

Obesity-induced inflammation originating from expanding adipose tissue interferes with insulin sensitivity. Important metabolic effects have been recently attributed to IL-1β and IL-18, two members… (More)

Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1α, IL-1β or IL-1 receptor type I.

• Leo A B Joosten, Frank L van de Veerdonk, +9 authors Mihai G Netea
• APMIS : acta pathologica, microbiologica, et…
• 2010

The role of intereukin-1 (IL-1) in mortality caused by endotoxaemia remains controversial. While IL-1 receptor antagonist (IL-1Ra) protects mice from lethal endotoxaemia, mice deficient in IL-1β… (More)

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