Giacomo Cuttone

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Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Its functionality and modeling capabilities continue to be extended,(More)
PURPOSE To analyse changes of cell inactivation and proliferation under therapeutic irradiation conditions along the proton spread out Bragg peak (SOBP) with particular emphasis on its distal declining edge. MATERIALS AND METHODS HTB140 cells were irradiated at four positions: plateau, middle, distal end and distal declining edge of the 62 MeV proton(More)
PURPOSE To measure the ability of protons and gamma-rays to effect cell viability and cell survival of human HTB140 melanoma cells. MATERIALS AND METHODS Exponentially growing HTB140 cells were irradiated close to the Bragg peak maximum of the 62 MeV protons or with 60Co gamma-rays with single doses, ranging from 8 - 24 Gy. Cell viability using the(More)
Synthetic diamond is potentially one of the more interesting materials in the field of detectors applicable in dosimetry. It is, in fact, tissue equivalent (its atomic number, Z = 6, is very close to the actual atomic number of a biological tissue, Z = 7.5. Moreover it is not toxic and shows a high resistance to radiation damage, a high sensitivity and(More)
Diamond is potentially a suitable material for use as radiation dosimeter; the wide band gap results in low dark currents and low sensitivity to visible light, the high carrier mobility can give rapid response, the very high density of strong bonds in the crystal structure make diamond very resistant to radiation damage; moreover it is tissue equivalent.(More)
Due to their ballistic precision, apoptosis induction by protons could be a strategy to specifically eliminate neoplastic cells. To characterize the cellular and molecular effects of these hadrons, we performed dose-response and time-course experiments by exposing different cell lines (PC3, Ca301D, MCF7) to increasing doses of protons and examining them(More)
Phosphorylation of histone H2AX at serine 139 (gamma-H2AX) represents one of the earliest steps in DNA DSB signaling and repair, but the mechanisms of coupling this histone modification to DSB processing remain to be established. In this work, H2AX phosphorylation-dephosphorylation kinetics induced by low doses of gamma rays in MRC-5 human fibroblasts was(More)
Effects of single irradiation with gamma rays and protons on human HTB140 melanoma cell growth were compared. Exponentially growing cells were irradiated close to the Bragg peak maximum of the unmodulated 62 MeV protons, as well as with (60)Co gamma rays. Applied doses ranged from 8 to 24 Gy. Viability of cells and proliferation capacity were assessed 7(More)
Vladimir IVANCHENKO, John APOSTOLAKIS, Alexander BAGULYA, Haifa Ben ABDELOUAHED, Rachel BLACK, Alexey BOGDANOV, Helmut BURKHARD, Stéphane CHAUVIE, Pablo CIRRONE, Giacomo CUTTONE, Gerardo DEPAOLA, Francesco Di ROSA, Sabine ELLES, Ziad FRANCIS, Vladimir GRICHINE, Peter GUMPLINGER, Paul GUEYE, Sebastien INCERTI, Anton IVANCHENKO, Jean JACQUEMIER, Anton(More)