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We propose a set–valued framework for the well–posedness of birth– and–growth process. Our birth–and–growth model is rigorously defined as a suitable combination, involving Minkowski sum and Aumann integral, of two very general set–valued processes representing nucleation and growth respectively. The simplicity of the used geometrical approach leads us to(More)
OBJECTIVE Isoflurane is a volatile anesthetic that has a vasodilating effect on cerebral vessels producing a cerebral blood flow increase. Furthermore, it has been shown in animal studies that isoflurane, when used as a preconditioning agent, has neuroprotective properties, inducing tolerance to ischemia. However, it is not routinely used in neurointensive(More)
OBJECTIVE The aim of this study was to identify determinants of lymphatic failure in patients with endometrial cancer after definitive primary treatment. METHODS We observed 142 relapses in endometrial cancer patients who had primary surgery at our institution during the decade before 1994. We defined lymphatic failure as a relapse occurring on the pelvic(More)
OBJECTIVE The objective of our study was to identify pathologic factors predictive of tumor dissemination to paraaortic lymph nodes (LNs) in endometrial carcinoma. The identification of the risk factors may potentially facilitate selection of patients for radical surgery or radiotherapy directed to the paraaortic area (PAA). METHODS The study population(More)
OBJECTIVE To evaluate outcome and risk factors of acute renal failure in a surgical population with or without preoperative renal dysfunction. DESIGN Observational study. SETTING Intensive care unit at a University Hospital. PARTICIPANTS Five thousand sixty-eight consecutive adult patients who underwent cardiac surgery with cardiopulmonary bypass. (More)
OBJECTIVE The objective of this study was the assessment of prognostic factors in stage IIIA endometrial cancer. METHODS Between 1984 and 1993, 51 patients with stage IIIA endometrial cancer received definitive treatment at our institution. Thirty-seven patients had positive peritoneal cytologic findings only (stage IIIA1), and 14 had adnexal or uterine(More)
OBJECTIVE The purpose of this study was to evaluate the effects of volatile anesthesia versus total intravenous anesthesia on cardiac troponin release in off-pump coronary artery bypass grafting (OPCAB). DESIGN The authors performed a multicenter randomized controlled study to compare cardiac troponin release in patients receiving either volatile(More)
OBJECTIVE To test the feasibility and utility of a risk-adjusted, multicenter outcomes model for ovarian cancer surgery as a tool for quality improvement. METHODS Patient characteristics, intra-operative findings, procedures, and outcomes were assessed in primary advanced stage ovarian cancer cases from 3 independent centers. A surgical complexity score(More)
OBJECTIVE To assess determinants of peritoneal failure in endometrial cancer patients after definitive primary treatment. METHODS Of 599 patients with endometrial cancer who had primary surgery at our institution during the decade before 1994, 131 had relapse. We defined "peritoneal failure" as relapse when it occurred in the upper abdomen or involved the(More)