• Publications
  • Influence
Aldosterone-mediated regulation of ENaC α, β, and γ subunit proteins in rat kidney
Aldosterone stimulates sodium transport in the renal collecting duct by activating the epithelial sodium channel (ENaC). To investigate the basis of this effect, we have developed a novel set ofExpand
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Association of depression with malnutrition in chronic hemodialysis patients.
BACKGROUND Depression is the most common psychological complication and may increase mortality in chronic hemodialysis patients. Because depression could be associated with poor oral intake andExpand
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Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2.
Prostaglandin E(2) may antagonize vasopressin-stimulated salt absorption in the thick ascending limb and water absorption in the collecting duct. Blockade of prostaglandin E(2) synthesis byExpand
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Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-Cl co-transporter, and epithelial sodium channel.
  • Gheun-Ho Kim, J. Lee, +6 authors J. Han
  • Chemistry, Medicine
  • Journal of the American Society of Nephrology…
  • 1 November 2004
Thiazides have been used in patients with nephrogenic diabetes insipidus (NDI) to decrease urine volume, but the mechanism by which it produces the paradoxic antidiuretic effect remains unclear.Expand
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Impact of Burn Size and Initial Serum Albumin Level on Acute Renal Failure Occurring in Major Burn
Background: Acute renal failure (ARF) is not a rare occurrence in severe burns and is an important complication leading to an increase in mortality. The severity of the burn is largely determined byExpand
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Long-Term Adaptation of Renal Ion Transporters to Chronic Diuretic Treatment
  • Gheun-Ho Kim
  • Medicine
  • American Journal of Nephrology
  • 1 November 2004
Loop and thiazide diuretics are clinically useful to induce negative sodium balance. However, with chronic treatment, their effects tend to be blunted since the kidney adapts to diuretics. MolecularExpand
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Tempol or candesartan prevents high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats.
BACKGROUND Obesity has been strongly associated with the development and aggravation of hypertension and chronic kidney disease. To date, the systemic renin-angiotensin system (RAS) has been known toExpand
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Oxytocin Induces Apical and Basolateral Redistribution of Aquaporin-2 in Rat Kidney
  • U. Jeon, K. Joo, +7 authors J. Han
  • Biology, Medicine
  • Nephron Experimental Nephrology
  • 1 January 2003
The aquaporin-2 (AQP2) water channel is mainly located in the apical plasma membrane of collecting duct epithelial cells, but there has been some evidence of a moderate amount of basolateralExpand
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Hyponatraemia induced by low-dose intravenous pulse cyclophosphamide.
BACKGROUND Cyclophosphamide is an alkylating agent and was traditionally known to potentiate the renal action of vasopressin. Although low-dose intravenous pulse cyclophosphamide therapy is beingExpand
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Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2.
  • K. Joo, U. Jeon, +8 authors J. Han
  • Medicine
  • Nephrology, dialysis, transplantation : official…
  • 1 October 2004
BACKGROUND The antidiuretic effect of oxytocin in humans is controversial. Urinary excretion of aquaporin-2 (AQP2) can be used as an index of the action of vasopressin on the kidney. We investigatedExpand
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