Ghang Lee

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Ultraviolet light B (UVB), contained in sunlight, induces damaging effects on skin by impairing cells in the epidermis and dermis. In particular, keratinocytes in the epidermis are those cells which are mainly affected by UVB light. UVB radiation induces cell death, growth arrest, DNA damage and restricts cell migration. Various phytochemicals have been(More)
This paper presents a linguistic framework for developing a formal knowledge acquisition method. The framework is intended to empower domain experts to specify information required by activities in design, engineering, manufacturing, and maintenance processes. The longer-term goal of the framework is to (semi-)automatically derive a data model from product(More)
Accumulating evidence indicates that reactive oxygen species (ROS) are an important etiological factor for the induction of dermal papilla cell senescence and hair loss, which is also known alopecia. Arctiin is an active lignin isolated from Arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. In the present study, we(More)
Buildings are complex products containing relatively large numbers of distinct parts that are collected in multiple assemblies for different design, analysis and production purposes. Modeling buildings in fully parametric 3D CAD systems offers numerous benefits in terms of productivity, the ability to rapidly generate design alternatives at different(More)
A product model is a formal and structured definition of product information. The most common procedure for defining a product data model is to first describe the business and/or engineering process in a formal process model, then to create a product data model based on the process model. However, there is a logical gap between process modeling and product(More)
We explore the reasons why advanced information technology applications have not been adopted by the AEC industry. Within the industry, however, some sectors have made significant moves toward adoption of advanced IT. By examining these areas of success, we propose a framework for the incremental conversion of the AEC industry to fully incorporate advanced(More)
SUMMARY: We report on a large-scale effort to integrate advanced design and engineering information technologies (IT) in the North American precast/prestressed concrete industry. The effort has been undertaken by a consortium of precast producer companies formed specifically for the task. The effort involved significant process modeling work, using a unique(More)
The aim of this study was to investigate the mechanisms by which troxerutin protects cells against ultraviolet B (UVB) radiation. First, we demonstrate that pre-treatment with troxerutin protects normal human dermal fibroblasts (nHDFs) against UVB-induced cytotoxicity. As shown by migration assay and DNA repair analysis, troxerutin increased cell migration(More)
This article reviews a method for generating a product model from user data and introduces 12 design patterns for resolving conflicts that may occur in the integration and normalization process. The generating method and design patterns were evaluated during a project to integrate the product models collected from three different precast concrete companies(More)