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Use of the single cell gel electrophoresis (comet assay) for comparing apoptotic effect of conventional antibodies versus nanobodies.
The large molecular size of antibodies is considered one major factor preventing them from becoming more efficient therapeutically. It is well established that all camelids have unique antibodiesExpand
Role of Gut-Brain Axis in the Aetiology of Neurodevelopmental Disorders with Reference to Autism
Neurodevelopmental disorders, especially in children, result in brain and nervous system damage. These may result from environmental contaminants, intrauterine environment, infectious diseases orExpand
Isolation of antimicrobial peptides from Apis florae and Apis carnica in Saudi Arabia and investigation of the antimicrobial properties of natural honey samples
Abstract As part of the ongoing search for novel antimicrobial agents and their use in singular or combined drug therapy, peptide fractions of molecular weights about 14.500 and 15.00 kDa wereExpand
The neurotoxic effect of clindamycin - induced gut bacterial imbalance and orally administered propionic acid on DNA damage assessed by the comet assay: protective potency of carnosine and carnitine
BackgroundComet assay is a quick method for assessing DNA damage in individual cells. It allows the detection of single and double DNA strand breaks, which represent the direct effect of someExpand
Prevention of Bacterial Biofilm Formation on Soft Contact Lenses Using Natural Compounds
PurposeIn eye care field, contact lenses (CL) have a great impact on improving vision, but their use can be limited by ocular infection. CL- associated infections can be reduced by good attention toExpand
Incidence of Helicobacter pylori infection and their clarithromycin-resistant strains in otitis media with effusion regarding phenotypic and genotypic studies.
Helicobacter pylori (H. pylori) are pathogenic bacteria that infect a half of the human population, colonize gastric mucosa and can be found in gastric juice. Reflux of gastric juice has beenExpand
Evaluation of antidiphtheria toxin nanobodies.
  • Ghada H. Shaker
  • Biology, Medicine
  • Nanotechnology, science and applications
  • 17 June 2010
Nanobodies are the smallest fragments of naturally occurring single-domain antibodies that have evolved to be fully functional in the absence of a light chain. Conventional antibodies areExpand
Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters
BackgroundPropionic acid (PA) found in some foods and formed as a metabolic product of gut bacteria has been reported to mimic/mediate the effects of autism. The present study was undertaken toExpand
Comparative study on the protective effect of carnosine and carnitine against pro-inflammatory/pro-oxidant effects of clindamycin and propionic acid administrations to hamsters
This study aimed to compare the neuroprotective potency of carnosine and carnitine supplements against the proinflammatory and prooxidant effects of orally administrated propionic acid andExpand
Impact of specific inhibitors on metallo-β-carbapenemases detected in Escherichia coli and Klebsiella pneumoniae isolates.
Carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by extended-spectrum beta lactamases producing Enterobacteriaceae. The emergence ofExpand