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BACKGROUND Whereas several authors recently reported a positive association between the alpha2-macroglobulin gene (A2M) and late-onset AD (LOAD), others were unable to replicate these findings. Early-onset AD (EOAD) is defined as onset age <65 years. Virtually all patients with LOAD are >65 years of age. OBJECTIVE To evaluate the role of A2M in AD, the(More)
The beta-site of beta-amyloid precursor protein cleaving enzyme (BACE) cleaves the beta-amyloid (Abeta) precursor protein at the N-terminal end of Abeta, allowing for the production of Abeta by C-terminal gamma-secretase cleavage. We hypothesized that over-activity of BACE might lead to the overproduction of Abeta, hence causing Alzheimer's disease (AD).(More)
Age-related macular degeneration (ARMD) is a multifactorial disease, with unknown etiology, which represents one of the main causes of legal blindness. At this moment, the only treatment for ARMD is symptomatic and concerns the distinction of the choroidal neovascularisation (CNV). There are many therapeutical procedures, and their classification is(More)
The paper presents the main clinical and histopathological research, relevant for the evolution of concepts regarding the terminology and classification of MDO. Because of the insufficient knowledge of the etiopathogenic under-stratum of the affection, a thorough classification could not have been elaborated until now. We propose a classification based on(More)