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Elevated circulating angiotensin (Ang) II levels, dietary sodium, and sympathetic stimulation are recurrent themes of hypertension research, but their in vivo interaction in physiologically meaningful doses has not been adequately investigated. In this study, the interaction of a subpressor dose of Ang II (50 ng. kg(-1). min(-1) SC), 2% NaCl diet, and(More)
We investigated whether the slow pressor action of small doses of angiotensin II (ANG II) administered to rats was accompanied by the development of structural vascular changes. Male Sprague-Dawley rats (350 to 400 g) were given ANG II intraperitoneally, 200 ng/kg/min, for 7 to 10 days or 6 weeks, or 100 ng/kg/min for 6 weeks. Sham-treated rats were(More)
Femoral vein (FV) pressure-volume relationships were measured in vitro in 14 dogs with chronic (more than 4 weeks), one-kidney perinephritic hypertension and in 13 unilaterally nephrectomized normotensive control dogs. Segments of FV were also examined histologically and analyzed for their water and electrolyte contents. Compared to controls: (I) the FV(More)
Despite widespread treatment of hypertension, stroke continues to be the third leading cause of death in the United States. Antihypertensive therapy is more effective in preventing hemorrhagic strokes than ischemic strokes. In order to understand the reasons why antihypertensive therapy is only partially successful in the eradication of ischemic strokes,(More)
To investigate the rate of development of left ventricular hypertrophy, left ventricular wall thickness was measured with M mode echocardiography in 12 unanesthetized dogs for several weeks before and for 8 weeks after the induction of hypertension. Hypertension was produced by wrapping one kidney in silk an performing contralateral nephrectomy 2 weeks(More)
We tested, in the early stage of angiotensin II (ANG II)-induced hypertension, whether sympathectomy prevented the autopotentiation of vasoconstrictor responses by ANG II and, in the chronic, established phase of hypertension, whether the antihypertensive effect of sympathectomy, if any, was related to the prevention of structural vascular changes.(More)
OBJECTIVES The role of salt sensitivity in arterial stiffening and the structural basis of reduced arterial distensibility were investigated in Dahl salt-sensitive (DS) rats. METHODS Three-month-old male DS rats received a normal (0.7% NaCl) or a high-sodium (2% NaCl) diet for 3 months. Dahl salt-resistant (DR) rats were controls. Pressure-volume(More)
We used the gracilis muscle vascular bed to bioassay blood from the two renal veins, vena cava, and aorta continuously for the presence of vasoactive agents before and for 45 minutes after partial occlusion of the left renal artery in dogs. Compared to comparable blood samples from control dogs, left renal venous, vena caval, and aortic blood, but not right(More)