Gevorg Stepanyan

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The new oral anticoagulants (NOAC), dabigatran and rivaroxaban, have been demonstrated to be at least equivalent to warfarin for preventing cardiac thromboembolism (TE) in patients with atrial fibrillation (AF). However, there is limited data regarding use around catheter ablation (CA) procedures. We evaluated the risk of bleeding and TE complications(More)
The antitumor properties of 2-imidazolinyl-2-hydrazones of acetophenones with various substituents in the benzene ring have been studied. High activity is found for 4-amyloxy-3-nitroacetophenone 2-imidazolinyl-2-hydrazone, which points to the expediency of its further investigation.
T h e 1 b e n z y l s u b s t i t u t e d i m i d a z o l e s ( I V g a n d h ) w e r e o b t a i n e d b y t h e a l k y l a t i o n o f t h e i s o d i u m s a l t o f 4 ( 5 ) ( 4 a c e t y l a m i n o p h e n y l ) i m i d a z o l e w i t h b e n z y l c h l o r i d e w i t h s u b s e q u e n t d e a c e t y l a t i o n o f t h e 1 b e n z y l 4 ( 4 a c(More)
4(5)-Substituted imidazoles are viewed with interest as possible antagonists of the nucleic acid metabolism of 4(5)-aminoimidazole-5(4)-carboxylamide. A search is being continued in that area for new antitumor compounds among the derivatives of 4-aminoimidazole-5-carboxylic acid [3, 14]. 4,5-aminonitroimidazole [4], and 4,5-nitro(amlno)thioimidazole [15,(More)
The initial reagents were (3-methyl-4-alkoxybenzyl)malonates (I) obtained by reaction of the corresponding 3-methyl-4-alkoxybenzyl chlorides with malonic ester in the presence of sodium ethylate; the procedure was analogous to that described in [2]. Subsequent cyclization of the substituted malonic esters I with thiourea or guanidine hydrochloride in(More)
The prevalence of atrial fibrillation increases significantly with age, affecting nearly 10 % of adults greater than 80 years of age. Complications from atrial fibrillation, including stroke, also increase with age. Medical therapy includes anticoagulation, ventricular rate control, and if symptoms persist, maintenance of sinus rhythm with antiarrhythmic(More)
Previously [1 – 3], we reported on S-substituted 1-benzyl-4-nitro-5-thioimidazoles possessing antitumor, mutagen, and antimutagen properties. In continuation of these investigations, we have synthesized a series of 4-methylthiosemicarbazides V and hydrazonohydrazides VI based on 1-methyland 1-benzyl-4-nitroimidazole-5thioacetic acid hydrazides (IV). The(More)
A series of new 2-S-substituted pyrimidine derivatives has been synthesized via the interaction of 2-mercaptopyrimidines with various alkylbromides, chloracetamide, and unsubstituted and substituted benzyl chlorides. The synthesized compounds have been tested with respect to antitumor activity.
N s u b s t i t u t e d p y r i m i d i n e s wi th p a l k o x y b e n z y l g r o u p s have been d e s c r i b e d in e a r l i e r r e p o r t s [1-3]. In con t inua t ion of t h e s e s t u d i e s , in o r d e r to e l u c i d a t e the r e l a t i o n s h i p of b i o l o g i c a l p r o p e r t i e s to s t r u c t u r e , we have s y n t h e s i z(More)
We synthesized new copper complexes of 4-methyl-, 4-phenyl-, 4-(4-alkoxybenzyl)-substituted thiosemicarbazones of 2-formylfuran and 2,2-dimethyl-4-formyltetrahydropyran. We discuss the spectral data and compare the antitumor properties of the ligands and complexes. The ligands were found to have a high therapeutic efficacy.