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A series of glycolic and mandelic acid derivatives was synthesized and investigated for their factor Xa inhibitory activity. These analogues are highly potent and selective inhibitors against fXa. In a rabbit deep vein thrombosis model, compound 26 showed significant antithrombotic effects (81% inhibition of thrombus formation) at 1.1 microM plasma… (More)
Park, Geunhyung, "Characterization of actuator behaviors of ferrogels obtained from physical and chemical cross-linking methods" Figure 17: The schematic of mechanism of MRE with interaction between magnetic particles and matrix under magnetic fields..
A series of potent and selective factor Xa inhibitors was synthesized using various readily available amino acids as central templates. The most potent compound displays IC(50) of 3 nM.