The significance of the rabbit's septum as a relay station between the midbrain and the hippocampus. I. The control of hippocampus arousal activity by the septum cells. Hippocampus theta waves of unanesthe-tized, curarized rabbits are triggered by cells in Broca's diagonal band: these bursting cells are phaselocked with the theta waves. Phase angles are… (More)
The effect of a benzodiazepine antagonist, ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5a] [1,4]benzodiazepine-3-carboxylate (Ro 15-1788), on the cerebello-rubral rhythm induced by a water soluble benzodiazepine derivative (medazepam hydrochloride) or by a barbiturate (pentobarbital sodium) was investigated in the rabbit. The frequency of this… (More)
The discharge of cerebellar neurons was investigated in the rabbit and the rat under the influence of pentobarbital, diazepam or medazepam. In the rabbit, these drugs are known to induce a rhythm ranging between 4 and 25 Hz in the red nucleus (RN) and the cerebellum (Cb). Purkinje cells (P cells) in the intermediate zone of the cerebellar cortex as well as… (More)
Harmaline induces synchronous rhythms in both the cerebellum and the red nucleus of the rabbit. The level of synchronization is lower in the red nucleus than in the cerebellar cortex, probably because the cerebello-rubral pathway and the red nucleus neurons only participate poorly in the harmaline-induced olivo-cerebellar rhythm.
The spasmolytic activity of six commonly used benzodiazepines was investigated on isolated guinea-pig ileum preparation. All six substances proved to be non-competitive antagonists of carbachol and barium chloride, the pD'2 values ranging between 3.23 and 4.37 in the presence of either agonist. The significance of these findings is discussed.
The electrocortical activity and the antibiotic concentration in serum and CSF were investigated in rabbits after i.v. administration of benzylpenicillin, ampicillin and oxacillin. In contrast to ampicillin and oxacillin, benzylpenicillin induced a pronounced epileptogenic activity. The different epileptogenic activity of the three penicillins cannot be… (More)
The electrocerebellogram of the rabbit was analysed by the Parcor-coefficients. The results show that this bioelectrical activity may be described by two Parcor-coefficients. No changes in these coefficients were found under the influence of physostigmine or scopolamine. Differences between the rhythms induced by pentobarbital, harmaline and strychnine were… (More)
The combined effects of halothane and various central depressants were studied in mice by means of an isobolographic method which allows the statistical evaluation of interactions. A loss of the righting reflex for at least 2 min was taken as the criterion for the synchronisation of the peak time of drug effects. All interactions turned out to be… (More)
The synergistic action of seven central depressants three benzodiazepines, two neuroleptics on barbiturate and morphine on the anesthetic activity of nitrous oxide was studied in mice. The benzodiazipines and among them nitrazepam and flunitrazepam were found to be the most potent drugs in this respect; morphine on the other hand was innefective even in… (More)
Electroencephalographic investigations of 4-aminopyridine were carried out in the non-anesthetized, immobilized rat. Under the influence of this agent seizure-like activity appeared in the hippocampal and subsequently in the neocortical recordings. This effect was antagonized by pretreatment with diazepam. The discussion deals with the central cholinergic… (More)