Gert van der Laan

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OBJECTIVE Worldwide, many workers experience occupational exposure to organic solvents, which may induce chronic solvent-induced encephalopathy (CSE). Disturbances within the frontostriatothalamic (FST) circuitry might explain the symptomatology of CSE. We tested the hypothesis of FST circuitry abnormalities in CSE, as well as associations with performance(More)
BACKGROUND Long-term exposure to organic solvents may lead to chronic solvent induced encephalopathy (CSE) in painters. In combination with reduction of exposure, a workers' health surveillance programme was developed, resulting in a three-stage CSE screening procedure for early neurobehavioural changes possibly predicting chronic health effects. The(More)
Long-term exposure to organic solvents can result in damage of the central nervous system. The WHO recognises the following stages: organic affective syndrome, mild chronic toxic encephalopathy (CTE), and severe CTE. There is no golden standard for the diagnosis of CTE. Mild CTE is characterised by fatigue, mood disturbances, memory and attention disorders.(More)
To determine the pattern of follicular growth during oestrus and the relationship with estradiol and luteinizing hormone in ovulating and non-ovulating cows, three groups of (n = 10), thirty cyclic, Bos indicus cows were synchronized with CIDR, consecutively at 9-day intervals. Twenty-four hours after implant withdrawal, all cows synchronized in the same(More)
Nanotoxicology link between India and European Nations (NanoLINEN) is a consortium of 7 European laboratories and Indian Institute of Toxicology Research (CSIR Laboratory) from India to strengthen the research ties in the area of Nanomaterial Toxicology. The goal of this project is to develop robust risk assessment methodologies that will be useful for the(More)
doi:10.1093/occmed/kqv169 5. Bonneterre V, Faisandier l, Bicout D et al.; RNV3p. programmed health surveillance and detection of emerging diseases in occupational health: contribution of the French national occupational disease surveillance and prevention network (RNV3p). Occup Environ Med 2010;67:178–186. 6. panizza C, Bai E, Oddone E et al. lung cancer(More)
BACKGROUND Worldwide millions of workers are exposed to organic solvents. Long term exposure leads in some workers to the development of Chronic Solvent induced Encephalopathy (CSE). The first reports about CSE came from the European Nordic countries in the 1970s. In spite of decades of experience with this disease, little is known about the course and(More)
Fifty patients with histologically confirmed chronic glomerulonephritis (34 males, 16 females, average age 42 years) and 50 control patients, age and sex-matched, with a variety of internal diseases, were selected. Both cases and controls completed an extensive questionnaire and additional information was sampled by means of a personal interview, especially(More)