Gert Müller-Esch

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Hintergrund Beim akuten Myokardinfarkt (AMI) hat eine frühzeitige Reperfusionstherapie einen günstigen Einfluss auf Ventrikelfunktion und Prognose. Nach Beginn der Beschwerden eines Herzinfarktes warten Patienten oft mehrere Stunden bis zur Inanspruchnahme medizinischer Hilfe. Diese Entscheidungs-Zeit zwischen Symptombeginn und der Entscheidung medizinische(More)
Urodilatin (ANF(95-126)) is an analogue of the atrial natriuretic factor (ANF(99-126)), which has been isolated from human urine. Recently we have shown in healthy volunteers, that intravenous bolus injections of synthetic urodilatin produce more pronounced reductions of pulmonary arterial pressure than ANF(99-126). To compare haemodynamic and renal effects(More)
Patienten mit Diabetes mellitus haben beim akuten Myokardinfarkt (AMI) möglicherweise geringere Beschwerden oder häufiger asymptomatische Infarkte. Dies ist eine verbreitete klinische Auffassung. Daten zweier Register ins Krankenhaus aufgenommener AMI-Patienten (MITRA PLUS mit 18786 Patienten; Norddeutsches Register, NGR, 1042 Patienten mit detailiertem(More)
Objectives: Inhibition of neutral endopeptidase 24.11 (NEP) prevents degradation of plasma atrial natriuretic peptide (ANP), a substance with vasodilatory and natriuretic properties. The aim of the study was to investigate the haemodynamic and endocrine effects of the NEP inhibitor candoxatril in patients with congestive heart failure (CHF). Methods: In a(More)
Of 347 victims of out-of-hospital cardiac arrest 196 (56.5%) died before and 109 (31.4%) after admission to hospital, while 42 patients (12.1%) were discharged alive. The 37 patients (10.7%) discharged without severe hypoxic brain damage were assigned to the group with “good”, the remaining 310 patients to the group with “poor outcome”. From results of(More)
Urodilatin (ANF(95-126)), an analogue of the atrial natriuretic factor (ANF(99-126)), has recently been isolated from human urine. To study haemodynamic and renal effects of synthetic urodilatin, 18 healthy male volunteers (age 26.1 +/- 0.8 years; X +/- SEM) received i.v. bolus injections of urodilatin at doses of 1, 2 or 4 micrograms kg-1 body weight (bw)(More)
UNLABELLED Among patients presenting at the hospital with an acute myocardial infarction (AMI), about 2-6% are mistakenly discharged by emergency physicians. The relevance of diagnostic problems in the prehospital period of an AMI is unknown. We prospectively studied 421 patients seen by a primary care physician in the prehospital period of an AMI. Using a(More)
Moyamoya syndrome is characterized by the reticulated collateralization of the intracranial vasculature distal to an occlusion of proximal intracranial vessels. In the present study this pathology was visualized in 2 patients, aged 29 and 32 years, using transcranial color Doppler imaging (TCDI). Digital subtraction angiography in both patients revealed(More)
The effects of a continuous i.v. infusion of urodilatin at a dose of 30 ng kg-1 min-1 were studied in a patient with congestive heart failure. After 30 min, urodilatin had induced a marked stimulation of plasma cyclic GMP concentrations. In parallel haematocrit increased. No significant diuresis and no change of invasive haemodynamics was observed. After 2(More)
Primary chylopericardium is a rare disease with a highly variable clinical course. We report on a 24-year old female with chylopericardium detected during a pulmonary infection. Despite successful treatment of the infectious disease, the chylopericardium persisted and led to cardiac tamponade. From this case, as well as from the literature, it is intriguing(More)