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OBJECTIVE To assess the diagnostic accuracy of flow cytometric immunophenotyping in comparison with classic cytomorphology for diagnosing CNS localizations of hematologic malignancies, and to evaluate the implications of CSF pleocytosis and protein content in this context. METHODS We reviewed the results of diagnostic evaluations of all CSF samples(More)
To asses the quality of bone marrow cytology of hospital laboratories in the south-west Netherlands a proficiency testing program was implemented. Two sets of bone marrow and blood smears from two patients were sent to 20 hospital laboratories using a tight time schedule biannually. Required results consisted of differential counts of 500 bone marrow cells(More)
Embedded software development is moving towards the model-based paradigm to support the complexity of today's embedded systems, as they become more and more important and omnipresent in our daily lives. In this context, the Unified Modeling Language (UML) is a widely used standard. Code generators can be executed to generate source code from UML models.(More)
Model-based approaches to develop software for embedded systems are becoming increasingly important in the last ten years. In this context, it is desirable to carry out debugging at the model level in conjunction with the model-based development of embedded software. This paper presents such a model-based debugging approach which can be used to visualize(More)
Embedded software engineering very often involves development of complex, mission critical software; wherein it is imperative that the developed software fulfills its requirements to achieve high quality. In such cases, there are several advantages of using specialized Requirements Management (RM) tools for managing the requirements. Critical timing(More)
In embedded software engineering, timing requirements are among the foremost non-functional requirements that have to be fulfilled. Therefore, there are specialized tools for analyzing and validating the timing behavior in embedded software. On the other hand, Model Driven Development (MDD) is considered as the next paradigm shift to address the increasing(More)
The increasing complexity of realtime embedded software systems necessitates them to support a variety of functions. Therefore, a practice is to split the overall system into different sub-systems and use various (modeling) tools for describing different parts of the system. On the other hand, though guaranteeing realtime properties forms an integral part(More)
Model Driven Development (MDD) is deemed as a key to address the increasing complexity of software systems. It is imperative that the developed software fulfills the end-user's requirements. This implies that a collaboration between the Requirements Management (RM) tools and the modeling tools, enabling complete traceability and interfacing among these(More)
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