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Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
Reactive aldehydes are common carcinogens. They are also by-products of several metabolic pathways and, without enzymatic catabolism, may accumulate and cause DNA damage. Ethanol, which isExpand
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Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
Summary SLX4 binds to three nucleases (XPF-ERCC1, MUS81-EME1, and SLX1), and its deficiency leads to genomic instability, sensitivity to DNA crosslinking agents, and Fanconi anemia. However, it isExpand
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Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway
Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the mainExpand
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Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
Haematopoietic stem cells (HSCs) regenerate blood cells throughout the lifespan of an organism. With age, the functional quality of HSCs declines, partly owing to the accumulation of damaged DNA.Expand
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Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi Anemia
The evolutionarily conserved SLX4 protein, a key regulator of nucleases, is critical for DNA damage response. SLX4 nuclease complexes mediate repair during replication and can also resolve HollidayExpand
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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
Summary Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to life, and it can crosslink both DNA and proteins. However, the consequences of its accumulation areExpand
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Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells
Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies. Here we describe the features andExpand
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The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA
Fanconi anaemia (FA) is a rare, autosomal recessive, genetically complex, DNA repair deficiency syndrome in man. Patients with FA exhibit a heterogeneous spectrum of clinical features. The mostExpand
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Analysis of the Novel Fanconi Anemia Gene SLX4/FANCP in Familial Breast Cancer Cases
SLX4/FANCP is a recently discovered novel disease gene for Fanconi anemia (FA), a rare recessive disorder characterized by chromosomal instability and increased cancer susceptibility. Three of the 15Expand
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Maternal Aldehyde Elimination during Pregnancy Preserves the Fetal Genome
Maternal metabolism provides essential nutrients to enable embryonic development. However, both mother and embryo produce reactive metabolites that can damage DNA. Here we discover how the embryo isExpand
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