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  • Joel Randolph Hecht, Tanja Trarbach, +13 authors David Kerr
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2011 (First Publication: 20 May 2011)
  • PURPOSE PTK787/ZK 222584 (PTK/ZK; vatalanib), an orally active, multitargeted angiogenesis inhibitor, has shown tolerability and promising activity in early-phase studies, which led to a phase IIIContinue Reading
  • Eric Van Cutsem, Emilio Bajetta, +11 authors Edward Lin
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2011 (First Publication: 20 May 2011)
  • PURPOSE Treatment options for patients with previously treated metastatic colorectal cancer (mCRC) are limited, and treatments with differing mechanisms of action are needed. PTK787/ZK 222584Continue Reading
  • Ralf Schmidmaier, Philipp Baumann, Meral Simsek, Farshid Dayyani, Bertold Emmerich, Gerold Meinhardt
  • Medicine
  • Blood
  • 2004 (First Publication: 15 September 2004)
  • Primary drug resistance is a major problem in multiple myeloma, an incurable disease of the bone marrow. Cell adhesion-mediated drug resistance (CAM-DR) causes strong primary resistance. ByContinue Reading
  • Ralf Schmidmaier, K. Mörsdorf, Philipp Baumann, Bertold Emmerich, Gerold Meinhardt
  • Medicine
  • The International journal of biological markers
  • 2006 (First Publication: 1 October 2006)
  • BACKGROUND/AIMS Multiple myeloma is an incurable disease and patients eventually die of disease progression due to drug resistance. VLA-4 (very late antigen 4), VCAM (vascular adhesion molecule),Continue Reading