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Islet architecture: A comparative study
Emerging reports on the organization of the different hormone-secreting cell types (alpha, glucagon; beta, insulin; and delta, somatostatin) in human islets have emphasized the distinct differencesExpand
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Islet Formation during the Neonatal Development in Mice
The islet of Langerhans is a unique micro-organ within the exocrine pancreas, which is composed of insulin-secreting beta-cells, glucagon-secreting alpha-cells, somatostatin-secreting delta-cells,Expand
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  • Open Access
Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of β-cell regeneration
The islet of Langerhans is a highly vascularized micro-organ consisting of not only beta-cells but multiple cell types such as α-, δ-, pancreatic polypeptide- and epsilon-cells that work together toExpand
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Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes
Human islets exhibit distinct islet architecture with intermingled alpha- and beta-cells particularly in large islets. In this study, we quantitatively examined pathological changes of the pancreasExpand
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  • Open Access
No mantle formation in rodent islets -- the prototype of islet revisited.
Emerging reports on human islets emphasize distinct differences from the widely accepted prototype of rodent islets, raising questions over their suitability for human studies. Here we aim atExpand
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Quantification of islet size and architecture
Human islets exhibit distinct islet architecture particularly in large islets that comprise of a relatively abundant fraction of α-cells intermingled with β-cells, whereas mouse islets show largelyExpand
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Formation of pancreatic islets involves coordinated expansion of small islets and fission of large interconnected islet-like structures.
The islets of Langerhans, micro-organs for maintaining glucose homeostasis, range in size from small clusters of <10 cells to large islets consisting of several thousand endocrine cells. Islet sizeExpand
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Quantification of pancreatic islet distribution in situ in mice.
Tracing changes of specific cell populations in health and disease is an important goal of biomedical research. Precisely monitoring pancreatic beta-cell proliferation and islet growth is aExpand
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The fractal spatial distribution of pancreatic islets in three dimensions: a self-avoiding growth model.
The islets of Langerhans, responsible for controlling blood glucose levels, are dispersed within the pancreas. A universal power law governing the fractal spatial distribution of islets inExpand
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Coating Human Pancreatic Islets With CD4+CD25highCD127− Regulatory T Cells as a Novel Approach for the Local Immunoprotection
Objectives:To develop a novel approach for local immunoprotection using CD4+CD25highCD127– T regulatory cells (Tregs) attached to the surface of the islets before transplantation. Background:TregsExpand
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  • Open Access