Germaine Săvoiu

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Systemic inflammation associated with chronic obstructive pulmonary disease (COPD) is a risk factor for the development of cardiovascular events. The aim of the present study performed in Guinea pigs chronically exposed to cigarette smoke was to assess the reactivity of rings of pulmonary artery and thoracic aorta isolated in organ bath. Twenty animals were(More)
UNLABELLED Intima-media thickness (IMT) of the carotid arteries assessed noninvasively by ultrasonography is now validated as a sensitive marker for atherosclerosis and it is directly associated with increased risk of cardiovascular disease. Hyperuricemia (HU) is a well-recognized risk factor for cardiovascular diseases. AIM To evaluate the correlations(More)
UNLABELLED Endothelial vasodilator dysfunction assessed by brachial artery flow-mediated dilatation (FMD) and carotid intima-media thickening (IMT) are two indicators of subclinical atherosclerotic disease. The aim of the study was to observe if there is a relationship between FMD and IMT in a group of hypertensive patients. MATERIAL AND METHOD We(More)
Cigarette smoking is well recognized as a major risk factor for atherosclerosis in men and women. Brachial flow-mediated dilation (FMD) is a physiologic measure and carotid intima-media thickness (IMT) is an anatomic structural measure of subclinical atherosclerosis. The purpose of this study was to observe the effects of cigarette smoking expressed in(More)
In vitro, several reactive oxygen species have been reported to induce constriction of the airways smooth muscle. The purpose of this paper was to study the reactive oxygen species (hypochlorite) effect on the tracheal smooth muscle in vitro and the prevention effect of Nacetyl-cysteine (NAC) and mepyramine (10 M), a histamine H1-receptor antagonist. There(More)
Cardiovascular diseases represent the major cause of mortality in Europe, both in females and males, and it refers to a large number of potentially fatal diseases including coronary artery diseases (CAD) and arterial hypertension [1]. CAD also known as ischemic heart disease, manifests in two major symptoms: angina and heart attack. The risk factors that(More)
An important feature of the pathophysiology of COPD patients is represented by the remodelling of pulmonary vasculature. Within this process, a pathogenic element might be the endothelial dysfunction induced by the combined effect of several factors such as: cigarette smoke, inflammatory mediators, hypoxia, mechanical stress, whose contribution differs(More)
Hyperuricemia (HU) is associated with hypertension, vascular disease, and renal disease and is a well recognized risk factor for cardiovascular diseases. Carotid Intima-media thickness (IMT) of the carotid arteries assessed noninvasively by ultrasonography is now validated as a sensitive marker for atherosclerosis and it is directly associated with(More)
Worldwide, nearly 8 million premature deaths, 54% of stroke cases and 47% of ischemic heart disease cases were attributable to high blood pressure (BP >115 mm Hg systolic) (Ruilope, 2011). It is widely known that arterial hypertension has effects on target organs like the brain, the heart and the kidney. Now a large body of evidence on the crucial role of(More)