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UNLABELLED Intima-media thickness (IMT) of the carotid arteries assessed noninvasively by ultrasonography is now validated as a sensitive marker for atherosclerosis and it is directly associated with increased risk of cardiovascular disease. Hyperuricemia (HU) is a well-recognized risk factor for cardiovascular diseases. AIM To evaluate the correlations(More)
UNLABELLED Oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Increased wall thickness precedes plaque formation and noninvasive B-mode ultrasonographic measurement of IMT is considered a useful marker of the development of the carotid atherosclerosis. MATERIAL AND METHOD The present study was designed to assess the(More)
UNLABELLED Endothelial vasodilator dysfunction assessed by brachial artery flow-mediated dilatation (FMD) and carotid intima-media thickening (IMT) are two indicators of subclinical atherosclerotic disease. The aim of the study was to observe if there is a relationship between FMD and IMT in a group of hypertensive patients. MATERIAL AND METHOD We(More)
Worldwide, nearly 8 million premature deaths, 54% of stroke cases and 47% of ischemic heart disease cases were attributable to high blood pressure (BP >115 mm Hg systolic) (Ruilope, 2011). It is widely known that arterial hypertension has effects on target organs like the brain, the heart and the kidney. Now a large body of evidence on the crucial role of(More)
UNLABELLED The main changes of the plasma lipid profile in patients with endothelial dysfunction are the increased triglyceride content of the lipoprotein remnant particles, the presence of the small and dense LDL particles and the decreasing of the HDL-cholesterol level. MATERIAL AND METHOD Considering these observations, we performed "in vitro"(More)
An important feature of the pathophysiology of COPD patients is represented by the remodelling of pulmonary vasculature. Within this process, a pathogenic element might be the endothelial dysfunction induced by the combined effect of several factors such as: cigarette smoke, inflammatory mediators, hypoxia, mechanical stress, whose contribution differs(More)
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