Germain Manfouo-Foutsop

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CD4⁺ T cells are critical regulators of immune responses, but their functional role in human breast cancer is relatively unknown. The goal of this study was to produce an image of CD4⁺ T cells infiltrating breast tumors using limited ex vivo manipulation to better understand the in vivo differences associated with patient prognosis. We performed(More)
HTLV-I infected CD4+ T-cells lines usually progress towards a CD3- or CD3low phenotype. In this paper, we studied expression, kinetics, chromatin remodeling of the CD3 gene at different time-points post HTLV-I infection. The onset of this phenomenon coincided with a decrease of CD3 γ followed by the subsequent progressive reduction in CD3 δ, then CD3 ε and(More)
Our studies show that HIV-1 infection provokes a progressive defect in surface TCR/CD3 receptors due to the specific and escalating loss of CD3 g mRNA. The human CD3 g gene is transcribed from a weak, lymphoid-specific promoter with significant transcription initiation site heterogeneity in normal T cells. However, early after HIV-1 infection CD3 g(More)
Our studies show that HIV-1, HIV-2, and HTLV-I infection all provoke a progressive defect in surface T cell receptor expression. A specific loss of CD3γ transcripts is responsible for the defect after HIV-1 or HIV-2 infection. Alternatively, while CD3γ transcripts are lost first after HTLV-I infection, their reduction is followed several months later by a(More)
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