Gerhard Seeland

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BACKGROUND The cytotoxic agent bendamustine combines a purine-like benzimidazol and alkylating nitrogen mustard group. The clinically tolerated dose for single bolus bendamustine is 215 mg/m2, for fractionated therapy on four consecutive days 85 mg/m2. The maximum tolerated dose of a day 1 and 8 (q4w) 30 min infusion schedule was recently found to be 160(More)
Modem breeding programmes ensure good selection results to the breeder and reduce, at the same time, the genetic variation within and between the breeds of a given animal species. At present efforts are being made to counter that process and, through the establishment of gene pools, to maintain the genetic manifoldness of the useful animal species. These(More)
SUMMARY Milk performance data of cross-breds in the synthetic breed German Black Pied Dairy Cattle (SMR), that had calved for the first time between 1970 and 1984, were used to estimate individual cross-breeding effects on milk production traits. Three million pure-bred and cross-bred cows that were in their first lactation and had originated from(More)
Changes in genetic variation of sexual maturity, initial and 500-days egg production during 12 year of selection for these traits were estimated by investigating the changes of their h 2 coefficients. Three variants of calculations of h 2 were used utilizing the production records for period of 2, 3 or 4 consecutive generations respectively. The results(More)
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