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BACKGROUND Photodynamic therapy with a self-adhesive 5-aminolaevulinic acid (5-ALA) patch shows high efficacy rates in the treatment of mild to moderate actinic keratosis (AK) in short term trials. OBJECTIVES The purpose of the trial was to follow up patients after successful 5-ALA patch-PDT at 3 month intervals over a total period of 12 months. Patients(More)
Due to increasing interconnection, IT systems are confronted with more and more attacks. To address this problem , we have to consider security requirements from the beginning of the system development. In early phases of system development, it is common to use a hybrid system view which is based on an object oriented modeling of the application core and(More)
In this paper we outline a new process model for security engineering. This process model extends object oriented, use case oriented software development by systematic security requirements elicitation and realization. In particular, we integrate the modeling of security requirements, threat and risk analysis on the one hand with the modeling of business(More)
Change and evolution of business and technology imply change and evolution of development processes. Besides that for a certain enterprise and/or project we will usually integrate elements from a variety of existing process models, comprising generic standards as well as specific development methods. In this paper we propose a Process Framework which is(More)
Change and evolution of business and technology imply change and evolution of development processes. Besides that for a certain enterprise or a project we will usually integrate elements from a variety of existing process models, comprising generic standards as well as specific development methods. In this paper we propose a process model framework which is(More)
BACKGROUND Photodynamic therapy (PDT) is increasingly used for treatment of actinic keratoses (AKs) but is a cumbersome procedure. A thin self-adhesive patch (PD P 506 A) containing 5-aminolaevulinic acid (5-ALA) was developed to facilitate PDT. OBJECTIVES To investigate efficacy and safety of the patch in comparison with placebo-PDT (superiority design,(More)
OBJECTIVE To test the independent contributions of vascular endothelium, sympathetic activation and inhibition, vessel distensibility, and nociceptor-mediated vasodilation in both glabrous and hairy skin circulations. RESEARCH DESIGN AND METHODS We measured blood flow using laser Doppler techniques in 10 people with type 2 diabetes and 10 age- and(More)
A Software Development Process for a certain enterprise and/or a certain project will usually integrate elements from a variety of existing process models, comprising generic standards as well as specific development methods. Besides that, change and evolution of business and technology imply change and evolution of development processes. In this paper we(More)