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Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype

• Susann Fayyaz, Janin Henkel, +5 authors Burkhard Kleuser
• Diabetologia
• 2013

Enhanced plasma levels of NEFA have been shown to induce hepatic insulin resistance, which contributes to the development of type 2 diabetes. Indeed, sphingolipids can be formed via a de novo pathway… (More)

Stimulation of fat accumulation in hepatocytes by PGE2-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis

• Janin Henkel, Katja Frede, +5 authors Gerhard Paul Püschel
• Laboratory Investigation
• 2012

Hepatic steatosis is recognized as hepatic presentation of the metabolic syndrome. Hyperinsulinaemia, which shifts fatty acid oxidation to de novo lipogenesis and lipid storage in the liver, appears… (More)

NF-κBp65 and Expression of Its Pro-Inflammatory Target Genes Are Upregulated in the Subcutaneous Adipose Tissue of Cachectic Cancer Patients

• Rodolfo Gonzalez Camargo, Daniela Mendes dos Reis Riccardi, +12 authors Marilia Seelaender
• Nutrients
• 2015

Cancer cachexia, of which the most notable symptom is severe and rapid weight loss, is present in the majority of patients with advanced cancer. Inflammatory mediators play an important role in the… (More)

Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes.

• Janin Henkel, Frank Neuschaefer-Rube, Andrea Pathe-Neuschäfer-Rube, Gerhard Paul Püschel
• Hepatology
• 2009

UNLABELLED Hepatic insulin resistance is a major contributor to fasting hyperglycemia in patients with metabolic syndrome and type 2 diabetes. Circumstantial evidence suggests that cyclooxygenase… (More)

Oncostatin M produced in Kupffer cells in response to PGE2: possible contributor to hepatic insulin resistance and steatosis

• Janin Henkel, Daniela Gärtner, +4 authors Gerhard Paul Püschel
• Laboratory Investigation
• 2011

Hepatic insulin resistance is a major contributor to hyperglycemia in metabolic syndrome and type II diabetes. It is caused in part by the low-grade inflammation that accompanies both diseases,… (More)

The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes

• Frank Neuschaefer-Rube, Stefanie Lieske, +14 authors Andreas L Birkenfeld
• Diabetes
• 2014

Reduced expression of the INDY (I'm not dead yet) tricarboxylate carrier increased the life span in different species by mechanisms akin to caloric restriction. Mammalian INDY homolog (mIndy,… (More)

Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent…

• Frank Neuschaefer-Rube, Ricardo Hermosilla, +4 authors Gerhard Paul Püschel
• The Biochemical journal
• 2004

hEP4-R (human prostaglandin E2 receptor, subtype EP4) is a G(s)-linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization and internalization that depend… (More)

Control of hepatocyte metabolism by sympathetic and parasympathetic hepatic nerves.

• Gerhard Paul Püschel
• The anatomical record. Part A, Discoveries in…
• 2004

More than any other organ, the liver contributes to maintaining metabolic equilibrium of the body, most importantly of glucose homeostasis. It can store or release large quantities of glucose… (More)

Isolation and characterization of dipeptidyl peptidase IV from human placenta.

• Gerhard Paul Püschel, Rolf Mentlein, Eckhard W Heymann
• European journal of biochemistry
• 1982

Human placenta is surprisingly rich in post-proline dipeptidyl peptidase activity. Among various cell fractions, microsomes have the highest specific activity. A homogeneous enzyme preparation is… (More)

PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation.

• Nadine Wieneke, Karen Ildico Hirsch-Ernst, Manuela Kuna, Sander Kersten, Gerhard Paul Püschel
• FEBS letters
• 2007

A tight hormonal control of energy homeostasis is of pivotal relevance for animals. Recent evidence suggests an involvement of the nuclear receptor NR1i3 (CAR). Fasting induces CAR by largely unknown… (More)

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