Gerhard Müller

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Structurally guided design approaches to low-molecular-weight platelet aggregation antagonists addressing the platelet-associated heterodimeric cell surface receptor gpIIb/IIIa rely on comparative studies of an ensemble of conformationally and biologically characterized compounds, since no high-resolution structure of the receptor system is available. We(More)
Zusammenfassung Software Engineering ist eine komplexe Aufgabe, die von den Beteiligten ausgeprägte Kompetenzen in vie-len verschiedenen Bereichen fordert. Die Vermittlung dieser Kompetenzen über das reine Fachwissen hin-weg ist eine zentrale Aufgabe, die eine Software-Engineering-Ausbildung leisten muss, um Absolventen für den Einsatz in der Praxis zu(More)
CombiTool is a new computer program for the analysis of combination effects of biologically active agents. It performs model calculations and an analysis of experimental combination effects for two or three agents according to both the Bliss independence and the Loewe additivity criteria. Zero interaction response surfaces are calculated from single-agent(More)
—Cooperative sensor self-localization (CSL) in wireless networks usually requires the nodes to be equipped with specific ranging hardware including ultra-wideband or ultrasonic distance sensors. Such designs are not suitable for application in low-cost, low-power sensor networks. Here, we demonstrate how low-cost, low-power, asynchronous sensor nodes can be(More)
The present paper compares three different kinds of semiconductor gas sensing materials: metal oxides (MOX), hydrogen-terminated diamond (HD), and hydrogenated amorphous silicon (a-Si:H). Whereas in MOX materials oxygen is the chemically reactive surface species, HD and a-Si:H are covalently bonded semiconductors with hydrogenterminated surfaces. We(More)
After a decade of research in the field of wireless sensor networks the energy consumption remains the dominating constraint. Complex algorithms with non-negligible runtimes must be processed by resource-limited nodes, and therefore require in-depth knowledge of the temporal behavior of the software and hardware components. However, state-of-the-art(More)
In this paper, we present a methodology to establish an accurate and power-aware simulation of wireless sensor networks. As the design of software applications running on resource-constrained sensor nodes mainly influences both timing and power consumption in the network, it is crucial to include these components in the simulation. Besides considering the(More)