Gerhard Hägele

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A practical method was elaborated for the synthesis of (aminomethylene)bisphosphine oxides comprising the catalyst- and solvent-free microwave-assisted three-component condensation of primary amines, triethyl orthoformate and two equivalents of diphenylphosphine oxide. The method is also suitable for the preparation of (aminomethylene)bisphosphonates using(More)
Purpose. To validate our hypothesis that a bisphosphonate (BP) having a nitrogen-containing heterocyclic ring on the side chain, and with no hydroxyl on the geminal carbon would possess increased activity, and better oral bioavailability due to enhanced solubility of its calcium complexes/salts and weaker Ca chelating properties. Methods. A novel BP,(More)
Purpose. This work was aimed at synthesizing novel bisphosphonates (BPs) and examining them in comparison to clinically used BPs such as pamidronate and alendronate, and to tetracycline, in order to evaluate their potential as anticalcification and antiresorption agents. The correlation between the various models was examined in order to establish facile(More)
A convenient DNA-based identification system is described for testing the species origin of meat samples. Probes are generated by PCR with primers binding to species-specific satellite DNA and hybridized to DNA purified from meat. This method is more robust and versatile than methods based on oligonucleotide hybridization. With the exception of a slight(More)
The NMR titration methodology to determine acid dissociation constants in aqueous solutions is extended for pK(a) values between 0 and 2, where potentiometric titrations are no longer applicable. (1)H NMR spectra are acquired for single samples of constant acid concentration (e.g. 0.02M), controlled ionic strength (I=1M with HNO(3)/NaNO(3)) and varying pH.(More)
Infrared (4000-100 cm(-1)) spectra of aminomethyl-dimethyl-phosphine oxide and 15N-aminomethyl-dimethyl-phosphine oxide have been measured. Geometric parameters (bond distances and angles), net electronic charges and vibrational spectroscopic data of both compounds calculated at various levels of theory (B3LYP/6-31G* and Moeller-Plesset perturbational(More)
Dimeric rhodium(I) bis(carbonyl) chloride, [Rh(CO)(2)(mu-Cl)](2), is found to be a useful and convenient starting material for the syntheses of new cationic carbonyl complexes of both rhodium(I) and rhodium(III). Its reaction with the Lewis acids AlCl(3) or GaCl(3) produces in a CO atmosphere at room temperature the salts [Rh(CO)(4)][M(2)Cl(7)] (M = Al,(More)
t l 'ocknet werdcn ((;efrier tr(,ckn ung). l)ie Gleichgewichtsfeucht igkei t ist auch unter dem Gef r i e rpunk t tenlperaturabh~ingig. Die Troekr iungsgeschwhld igke i t yon Holz fiber 4 his 5 nun Dicke ist unter t0 ~' C sehr gei'ing. I)as Tempera tnrgefgI le kann in den t rocknenden Holzschichten sehr grol3 werden und weist auf den ger ingen(More)
Calculations reveal that the octahedral-trigonal prismatic-octahedral rearrangement has particularly low-energy barriers for MoF6, WF6, and (hypothetical) CrF6. Experimental evidence is obtained from the dynamic 19F NMR spectra of the derivatives CF3-CH2-O-MoF5, CF3-CH2-O-WF5, C6F5-O-MoF5, C6F5-O-WF5, and (CF3)3C-O-WF5. The ground-state structure of all(More)