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Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps.
The increasing use of tissue dosimetry estimated using pharmacokinetic models in chemical risk assessments in various jurisdictions necessitates the development of internationally recognized goodExpand
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  • Open Access
Combination of a higher-tier flow-through system and population modeling to assess the effects of time-variable exposure of isoproturon on the green algae Desmodesmus subspicatus and
A flow-through system was developed to investigate the effects of time-variable exposure of pesticides on algae. A recently developed algae population model was used for simulations supported andExpand
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Comparison of pesticide leaching models: results using the Weiherbach data set
Abstract The leaching of the herbicide isoproturon and the water tracer bromide in the profile of a silty loam soil at the Weiherbach Catchment area in Germany was simulated by eight differentExpand
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A toxicokinetic and toxicodynamic modeling approach using Myriophyllum spicatum to predict effects caused by short-term exposure to a sulfonylurea.
Toxicokinetic and toxicodynamic models are a promising tool to address the effects of time-variable chemical exposure. Standard toxicity tests usually rely on static concentrations, but theseExpand
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Mechanistic modelling of toxicokinetic processes within Myriophyllum spicatum.
Effects of chemicals are, in most cases, caused by internal concentrations within organisms which rely on uptake and elimination kinetics. These processes might be key components for assessing theExpand
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Role of submerged vegetation in the retention processes of three plant protection products in flow-through stream mesocosms.
Quantitative information on the processes leading to the retention of plant protection products (PPPs) in surface waters is not available, particularly for flow-through systems. The influence ofExpand
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Modelling ethoprophos and bentazone fate in a sandy humic soil with primary pesticide fate model PRZM-2
Abstract Primary pesticide fate models are powerful tools for ranking pesticides within an environmental contamination risk analysis context. The performance of primary pesticide root zone modelExpand
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Potential for the Adoption of Probabilistic Risk Assessments by End-Users and Decision-Makers
ABSTRACT In the area of risk assessment associated with ecotoxicological and plant protection products, probabilistic risk assessment (PRA) methodologies have been developed that enableExpand
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Recommendations to conduct and assess model calculations for the validation of simulation models
The use of simulation models within the registration of pesticides has been steadily increasing over the past years. Tberefore, the models' suitability for the intended field of use has to beExpand