Gerd Hoffmann

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There is increasing evidence that the hypercortisolemia in inflammatory diseases suppresses the elaboration of proinflammatory cytokines, thus protecting the host from its own defence reactions. In severe sepsis and septic shock cortisol levels are usually elevated, but some patients may have relative adrenal insufficiency. This may contribute to the(More)
A photometric method for the determination of phospholipase A is described, in which fatty acids are liberated from phosphatidylcholine and measured by a discontinuous enzymatic test. Optimal test conditions were evaluated using purified phospholipase A from human and porcine pancreas. The enzyme activities measured in normal human sera are in the range of(More)
The time courses of serum phospholipase A (PLA) and arterioalveolar oxygen differences (AaDO2) were compared in a group of 30 patients with severe multiple injuries. Evaluation of 391 measuring points revealed that high PLA (above 50 U/l) was associated with increased AaDO2 (above 150 mm Hg). Twelve patients who died having the symptoms of acute respiratory(More)
Fatty-acid synthase has been purified to homogeneity from human liver by a 3-step procedure including protamine sulfate/ammonium sulfate fractionation, affinity chromatography on 2',5'-ADP-Sepharose 4B and gel filtration on Sephacryl S-300. Both the human and rat fatty-acid synthase had similar characteristics regarding molecular mass, subunit structure,(More)
BACKGROUND Water-filtered infrared-A (wIRA) is a special form of heat radiation with a high tissue-penetration and with a low thermal burden to the surface of the skin. wIRA is able to improve essential and energetically meaningful factors of wound healing by thermal and non-thermal effects. AIM OF THE STUDY prospective study (primarily planned(More)
A striking sexual dimorphism has been found in the density of Met-enkephalin immunoreactive fibers in the periventricular region of the preoptic area in the rat: the enkephalinergic fiber system is much denser in females. The expression of this female-typical fiber plexus is regulated by the actions of gonadal steroids both during development and in(More)
The central portion of chronic wounds is often hypoxic and relatively hypothermic, representing a deficient energy supply of the tissue, which impedes wound healing or even makes it impossible. Water-filtered infrared-A (wIRA) is a special form of heat radiation with a high tissue penetration and a low thermal load to the skin surface. wIRA produces a(More)
BACKGROUND Multiple organ failure (MOF) is becoming the most common cause of death in patients in surgical intensive care units. In this respect, a multicenter study in four different groups of patients in surgical intensive care units was done to evaluate the role of phospholipase A2 (PLA2) in comparison with C-reactive protein (CRP) and polymorphonuclear(More)
Water-filtered infrared-A (wIRA), as a special form of heat radiation with a high tissue penetration and a low thermal load to the skin surface, can improve the healing of acute and chronic wounds both by thermal and thermic as well as by non-thermal and non-thermic effects. wIRA increases tissue temperature (+2.7 degrees C at a tissue depth of 2 cm),(More)