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  • N. Jung, Christian Lehmann, +6 authors Dirk Taubert
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2008 (First Publication: 1 August 2008)
  • Carrier-mediated transport across cell membranes is an important determinant of activity, resistance, and toxicity of chemotherapeutic agents including antiretroviral (ARV) drugs (ARDs). The organicContinue Reading
  • Suzanne M Ingle, Margaret May, +19 authors Jonathan A C Sterne
  • Medicine
  • Clinical infectious diseases : an official…
  • 2014 (First Publication: 24 April 2014)
  • Among HIV-infected patients who initiated antiretroviral therapy (ART), patterns of cause-specific death varied by ART duration and were strongly related to age, sex, and transmission risk group.Continue Reading
  • Christoph Wyen, Heidy Hendra, +18 authors Andrew Owen
  • Medicine, Biology
  • The Journal of antimicrobial chemotherapy
  • 2008 (First Publication: 4 February 2008)
  • OBJECTIVES The aim of this study was to investigate the frequency of CYP2B6 polymorphisms (according to ethnicity) and the influence of heterozygosity and homozygosity on plasma concentrations ofContinue Reading
  • Harry B. Gristick, Lotta von Boehmer, +8 authors Pamela J. Bjorkman
  • Biology, Medicine
  • Nature Structural &Molecular Biology
  • 2016 (First Publication: 12 September 2016)
  • HIV-1 vaccine design is informed by structural studies elucidating mechanisms by which broadly neutralizing antibodies (bNAbs) recognize and/or accommodate N-glycans on the trimeric envelopeContinue Reading
  • Christoph Wyen, Heidy Hendra, +20 authors Andrew Owen
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
  • 2011 (First Publication: 1 September 2011)
  • OBJECTIVES Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic clearance of efavirenz and single nucleotide polymorphisms (SNPs) in the CYP2B6 gene are associated with efavirenzContinue Reading
  • Marcus Hentrich, Marcel Berger, +16 authors Christian Hoffmann
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2012 (First Publication: 20 November 2012)
  • PURPOSE Although the outcome of patients with HIV-related Hodgkin lymphoma (HIV-HL) has markedly improved since the introduction of combined antiretroviral therapy, standard therapy is still poorlyContinue Reading