Gerd Bertram

Learn More
Ten adult patients with active HHV-6 variant A infections and clinical infectious mononucleosis-like disease (IM) were studied over a period of 32 weeks after onset of disease for their viral DNA load, changes in peripheral blood T-lymphocytes and subpopulations and frequency of cell death in peripheral blood cells. The data were collected as the basis for(More)
One hundred and thirteen cases of nasopharyngeal carcinoma (NPC) were classified histologically according to the WHO-, French and Cologne systems. The various histological tumor types were then correlated with data on Epstein-Barr virus (EBV) serology (EA, VCA, EBNA, CF, IgA-VCA). The results showed non-keratinizing carcinomas with lymphoid infiltration,(More)
From 1974 to 1985, 76 patients with nasopharyngeal carcinoma (NPC) received irradiation with curative intent and 14 with palliative intent in our department. Of the 76 patients, 59 presented with UICC stage IV. The 5-year actuarial survival rate was 41% and the relapse-free survival rate (RFS) 45%. The slides were reviewed according to the World Health(More)
A unique association of Epstein-Barr virus (EBV) with the undifferentiated nasopharyngeal carcinoma (NPC) is a well acknowledged phenomenon. We report here the detection of a factor present in the sera of NPC patients which inhibits the blastogenic response of lymphocytes from EBV seropositive individuals to EB virions or soluble antigens. This(More)
The sixth member of the human herpesvirus family, HHV-6, causes early childhood infection with subsequent latency and antibody prevalence of about 60-80%. Active infection is related to a number of acute and chronic diseases such as exanthem subitum, certain cases of infectious mononucleosis and other immunoproliferative syndromes, autoimmune disorders and(More)
Clinical infectious mononucleosis (IM) represents a benign self-limited form of lymphoproliferative disease which is usually caused by infection with Epstein-Barr virus (EBV). Microscopic characteristics of this lymphoproliferative disorder, however, are not ultimately specific for EBV infection, but can also be seen in infections with other lymphotropic(More)
A group of 54 patients with nasopharyngeal carcinoma (NPC) has been classified according to the TNM-staging-systems of the UICC (International Union Against Cancer), DAG (German Work Group "Clinical Oncology"), J.H.C. Ho/Hong Kong and the 2nd International Symposium on NPC, Kyoto 1977. For several parameters the patients have been classified for AJC(More)
From 1960--1980, 452 malignant tumors of the oro- and nasopharynx were observed in the Cologne university ENT-clinic. 313 tumors of the oropharynx and 119 of the nasopharynx could be reclassified using the current classifications of upper respiratory tract tumors (WHO and Cologne modification) and of malignant lymphomas (German Kiel and Rappaport(More)
Zur Strahlentherapie von malignen Tumoren im HNO-Bereich ist die genaue Kenntnis des Zielvolumens Voraussetzung. Die Bedeutung des Computertomogramms (CT) für die Strahlenthera-pieplanung soll am Beispiel des Nasopharynxcarcinoms (NPC) aufgezeigt werden. Es werden Planungs- und Fallbeispiele der häufigsten Primärtumorsituationen unter Einschluß der(More)