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OBJECTIVES A study was performed to investigate automatic detection of muscle artefact, using time domain and frequency domain methods. The evaluation focussed on epoch length and performance of detection. METHODS EEG data were recorded in 21 normal adult subjects for 50 min during awake state. Investigated positions included central, temporal and(More)
PURPOSE This study was designed to assess whether sleep disturbance is more frequent among patients with partial seizures and what impact on quality of life (QoL) sleep disturbance may have on patients with partial seizures. METHODS Questionnaire booklets were mailed to 1,183 patients from four Dutch clinics. Each patient was asked to find two age- and(More)
OBJECTIVES To evaluate the effects of adjunctive pregabalin 300 mg/day versus placebo on polysomnographic (PSG) variables in patients with well controlled partial seizures and subjectively reported sleep disturbance. METHODS An exploratory, 4-week, double-blind, randomized study in patients with well controlled partial seizures on AED monotherapy and(More)
PURPOSE A large multigenerational family with benign familial neonatal convulsions (BFNC) was revisited to identify the disease-causing mutation and to assess long-term outcome. METHODS We supplemented the original data with recent clinical and neurophysiologic data on patients and first-degree relatives, including information on seizure recurrence. We(More)
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