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Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.
A library of trisubstituted oxazoles, thiazoles, imidazoles (1,2,4- and 2,4,5-substituted) and imidazo[1,2-b]pyridines was prepared and evaluated in vitro as p38alpha inhibitors and in vivo inExpand
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Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.
A test library with three novel p38alpha inhibitory scaffolds and a narrow set of substituents was prepared. Appropriate combination of substituent and scaffold generated potent p38alpha inhibitors,Expand
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SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.
Benzoylpyridines and benzophenones were synthesized and evaluated in vitro as p38alpha inhibitors and in vivo in several models of rheumatoid arthritis. Oral activity was found to depend uponExpand
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