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BACKGROUND Diabetes-related lower limb amputations are associated with considerable morbidity and mortality and are usually preceded by foot ulceration. The available systematic reviews of aggregate data are compromised because the primary studies report both adjusted and unadjusted estimates. As adjusted meta-analyses of aggregate data can be challenging,… (More)
BACKGROUND Elevated plasma homocysteine concentrations have been associated with both cognitive impairment and dementia. However, it is unclear whether some cognitive domains are more affected than others, or if this relationship is independent of B12 and folate levels, which can also affect cognition. We examined the relationship between plasma… (More)
BACKGROUND Peripheral arterial disease (PAD) is a condition in which there is blockage or narrowing of the arteries that carry blood to the legs and arms. It is estimated to affect around 4.5% of people aged between 55 and 74 years within the UK. The most common symptom of PAD is intermittent claudication (IC), characterised by pain in the legs on walking… (More)
During the last decade liver surgery has become both safer and more widely practised1-4. Factors responsible include a greater appreciation of liver anatomy, improved anaesthesiology and perioperative care and technological advances such as the development of intraoperative ultrasonogra'phic imaging, improved retrac-tors, ultrasonic surgical aspirators,… (More)
The study of hepatic haemodynamics is of importance in understanding both hepatic physiology and disease processes as well as assessing the effects of portosystemic shunting and liver transplantation. The liver has the most complicated circulation of any organ and many physiological and pathological processes can affect it. This review surveys the methods… (More)
Hepatocellular carcinoma arising in a patient with genetic haemachromatosis, without cirrhosis, has only been described once previously. We present a patient with a 15 year history of genetic haemachromatosis who underwent resection of a hepatocellular carcinoma in a liver with normal architecture.
OBJECTIVES To assess the clinical effectiveness of thigh length versus knee length antiembolism stockings for the prevention of deep vein thrombosis (DVT) in surgical patients. DESIGN Systematic review and meta-analysis using direct methods and network meta-analysis. METHODS Previous systematic reviews and electronic databases were searched to February… (More)
IntroduCtIon Peripheral arterial disease (PAD) affects approximately 20% of patients aged ≥60 years.