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Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients. The pulmonary immune response in CF is characterized by an early and non-resolving activation of the innate immune system, which is dysregulated at several levels. Here we provide a comprehensive overview of innate immunity in CF lung disease, involving (i)(More)
BACKGROUND The development of COPD in subjects with alpha-1 antitrypsin (AAT) deficiency is likely to be influenced by modifier genes. Genome-wide association studies and integrative genomics approaches in COPD have demonstrated significant associations with SNPs in the chromosome 15q region that includes CHRNA3 (cholinergic nicotine receptor alpha3) and(More)
POSTERS Analysis of sterol regulation in the Saccharomycotina. Many fungal pathogens grow on superficial and in internal sites in infected hosts, regions that have considerably different oxygen levels. A better understanding of the influence of hypoxia (low oxygen) on virulence and pathogenesis may lead to improved treatments against systemic fungal(More)
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