Gerard M Kerins

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The present study investigated the whole-carcass residue carried by resistant and susceptible laboratory rat strains following 5, 10, or 20 d of feeding on a diet of 25 mg difenacoum/kg bait. The mean whole-carcass residue of difenacoum was determined by high-performance liquid chromatography to be between 0.52 and 0.74 mg/kg body weight in all three rat(More)
BACKGROUND Despite the fact that 80% of patients with heart failure are aged more than 65 years, recognition of cognitive impairment by physicians in this population has received relatively little attention. The current study evaluated physician documentation (as a measure of recognition) of cognitive impairment at the time of discharge in a cohort of older(More)
The half-lives and regeneration rates of clotting factors II, VII, and X in the plasma of anticoagulant-resistant and susceptible rats were determined. There is little or no difference in the half-lives of factors II and X in anticoagulant-resistant rats compared to susceptible rats, but the half-life of factor VII is longer in anticoagulant-resistant rats.(More)
1. A new test for identifying levels of difenacoum resistance in the Norway rat is described, based upon the differential physiological response to difenacoum administration. 2. This test is based on changes in blood clotting activity over 4 days, following administration of the rodenticide difenacoum in conjunction with menadione (vitamin K3). 3. The(More)
Resistance to 4-hydroxycoumarin anticoagulant rodenticides has been a problem in some local foci for a number of years. One method of managing resistance could be to use synergists in conjunction with anticoagulants. We investigated the effect of administering cholecalciferol and coumatetralyl alone and in a synergistic mixture to anticoagulant-resistant(More)
Difenacoum, a 4-hydroxycoumarin anticoagulant rodenticide with the same mode of action as warfarin, was fed to four strains of rat in medium oatmeal at 0.005% (w/w) for five days. The four rat strains had differing degrees of resistance to the anticoagulant difenacoum. Prothrombin time, factor X and fibrinogen concentration were monitored daily throughout(More)
In a series of 3 experiments with different experimental paradigms, feeding patterns of laboratory rats (Rattus norvegicus) were monitored in 2-choice feeding tests after intubation with a sublethal dose of an anticoagulant rodenticide. We report for the first time that contrary to accepted wisdom, anticoagulants can induce taste aversions. Furthermore, we(More)
After induced mutagenesis and transgenesis, genome editing is the next step in the development of breeding techniques. Genome editing using site-directed nucleases - including meganucleases, zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the CRISPR/Cas9 system - is based on the mechanism of double strand breaks.(More)
Effective health care for older adults requires that providers assess and manage sexual health needs with high priority. This assessment begins with an effective sexuality assessment tool. A two-step, research approach was undertaken to develop and test the Geriatric Sexuality Inventory (GSI). Literature and expert review resulted in a 34-item instrument(More)
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