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OBJECTIVES Sleep deprivation and alcohol both impair driving performance. This study assessed the interactive effect of low-dose alcohol and extended wakefulness. DESIGN Repeated-measures, crossover design evaluating psychomotor and driving function in a non-sleep-deprived state and after extended wakefulness with and without low-dose alcohol. SETTING(More)
STUDY OBJECTIVES Previous studies have demonstrated that as little as 18 hours of sleep deprivation can cause deleterious effects on performance. It has also been suggested that sleep deprivation can cause a "tunnel-vision" effect, in which attention is restricted to the center of the visual field. The current study aimed to replicate these behavioral(More)
Sleep loss, widespread in today's society and associated with a number of clinical conditions, has a detrimental effect on a variety of cognitive domains including attention. This study examined the sequelae of sleep deprivation upon BOLD fMRI activation during divided attention. Twelve healthy males completed two randomized sessions; one after 27 h of(More)
The main sources of stress reported by 423 Australian final-year high school students using the Academic Stress Questionnaire were school-related as expected. The highest sources of this stress were examinations and outcomes, too much to do, worry over future, making choices about career, studying for examinations, amount to learn, need to do well imposed(More)
Like enucleation, lateral hypothalamic (LH) lesions sever the connection between the retina and the pineal thereby simulating ambient exposure to constant darkness. While LH lesions have been employed to study either circadian function or Parkinson's disease (PD) independently, the application of such lesions to study circadian involvement specifically in(More)
Animal models for neuropsychiatric disorders are implemented for the purpose of investigating a single or multiple aspects of a specific disease entity. In Parkinson's disease (PD) several models have been utilised to study the biochemical and behavioural consequences of dopamine (DA) neurone degeneration with the intent of further understanding the(More)
Driving is a complex task, which can be broken down into specific cognitive processes. In order to determine which components contribute to drowsy driving impairments, the current study examined simulated driving and neurocognitive performance after one night of sleep deprivation. Nineteen professional drivers (age 45.3±9.1) underwent two experimental(More)
Ageing is associated with a decrease in the quality of night-time sleep with 30% of aged persons experiencing chronic insomnia. Treatment of insomnia typically involves the use of hypnotic medications and these have been associated with a range of negative outcomes in this population cohort. The development of age-related insomnia has been linked, in part,(More)
The aim of this study was to determine whether wrist actigraphy could be used to assess the daytime effects of stimulant medication in the treatment of narcolepsy. Nine subjects with narcolepsy/cataplexy (medicated and unmedicated) were compared with matched control subjects. Data were collected over 4 days in the subjects' home. It was found that the(More)
OBJECTIVES Excessive daytime sleepiness (EDS) is associated with significant personal and medical burden. However, there is little indication of the impact of these symptoms in the broader population. PARTICIPANTS AND METHODS We studied 946 men ages 24-92 years (median age, 59.4 [interquartile range {IQR}, 45-73 years]) and 1104 women ages 20-94 years(More)