Geraldine Chan

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BACKGROUND The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in several types of cancer including mesothelioma. Protein kinase CK2 affects several cell signaling pathways through the mechanism of phosphorylation. METHODS Protein and mRNA levels of CK2α and Gli1 were tested by quantitative(More)
Malignant pleural mesothelioma (mesothelioma) is a highly aggressive cancer without an effective treatment. Cul4A, a scaffold protein that recruits substrates for degradation, is amplified in several human cancers, including mesothelioma. We have recently shown that Cul4A plays an oncogenic role in vitro and in a mouse model. In this study, we analysed(More)
P l l The Suppression of Crk Inhibits the Metastatic Profile of Breast Cancer Cells Lines G. Chan,* S.P. Rodrigues, F. Halwani, S. Meterissian, M. Park. Surgery, McGill University, Montreal, QC, Canada. The Crk family of signaling adaptor proteins function in the pathways of proliferation, cytoskeletal organization, adhesion and migration. These processes(More)
Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73 human mesothelioma tumors, and significant correlation of MET and ERK5 expression was identified (P<0.05). We evaluated the doublecortin-like(More)
Malignant mesothelioma is an aggressive cancer that is resistant to current therapy. The poor prognosis of mesothelioma has been associated with elevated Yes-associated protein (YAP) activity. In this study, we evaluated the effect of targeting YAP in mesothelioma. First, we comprehensively studied YAP activity in five mesothelioma cell lines (211H, H2052,(More)
A traffic flow simulation has been developed to analyse traffic movements in the National University of Singapore (NUS). As part of a crisis management plan, the program's main function is to analyse the time needed for a full traffic evacuation in the case of an emergency. In addition, it also allows users to determine the shortest path for their journey(More)
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