Gerald T O'connor

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Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-living individuals who underwent(More)
Dose-response curves to methacholine were examined in 9 normal and 10 asthmatic volunteers to determine whether the relationship between dose and response can be adequately summarized by means of a single, continuous measure that is not censored at lower levels of bronchial responsiveness. Subjects underwent a standard methacholine challenge test. There was(More)
The Sleep Heart Health Study (SHHS) is a prospective cohort study designed to investigate obstructive sleep apnea (OSA) and other sleep-disordered breathing (SDB) as risk factors for the development of cardiovascular disease. The study is designed to enroll 6,600 adult participants aged 40 years and older who will undergo a home polysomnogram to assess the(More)
Of 22 randomized trials of rehabilitation with exercise after myocardial infarction (MI), one trial had results that achieved conventional statistical significance. To determine whether or not these studies, in the aggregate, show a significant benefit of rehabilitation after myocardial infarction, we performed an overview of all randomized trials,(More)
Gerald T. O'Connor, PhD, DSc; Stephen K. Plume, MD; Elaine M. Olmstead, BA; Laurence H. Coffin, MD; Jeremy R. Morton, MD; Christopher T. Maloney, MD; Edward R. Nowicki, MD; Drew G. Levy, MPH; Joan F. Tryzelaar, MD; Felix Hernandez, MD; Lawrence Adrian, PA-C; Kevin J. Casey, PA, RN; Dale Bundy, PA, RN; David N. Soule, BA; Charles A.S. Marrin, MB, BS; William(More)
OBJECTIVE A prospective regional study was conducted to determine if the observed differences in in-hospital mortality rates associated with coronary artery bypass grafting (CABG) are solely the result of differences in patient case mix. DESIGN-Regional prospective cohort study. Data including patient demographic and historical data, body surface area,(More)
OBJECTIVE To test the impact of physician education and facilitator assisted office system interventions on cancer early detection and preventive services. DESIGN A randomised trial of two interventions alone and in combination. SETTING AND SUBJECTS Physicians in 98 ambulatory care practices in the United States. INTERVENTIONS The education(More)
BACKGROUND Mediastinitis is a dreaded complication of coronary artery bypass surgery (CABG). The long-term effect of mediastinitis on mortality after CABG has not been well studied. METHODS We examined the survival of 15,406 consecutive patients undergoing isolated CABG surgery from 1992 through 1996. Patient records were linked to the National Death(More)
The use of adrenocorticoids to reduce the morbidity associated with laryngotracheitis (croup) remains controversial despite ten published reports of randomized trials involving 1,286 patients. To determine whether, viewed in aggregate, these studies demonstrate a significant benefit of steroid treatment for this disorder, a meta-analysis of the nine(More)