Gerald Mcgwin

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OBJECTIVE The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new knowledge regarding the immunology of SLE. METHODS(More)
Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329(More)
CONTEXT Motor vehicle crash risk in older drivers has been associated with visual acuity loss, but only weakly so, suggesting other factors contribute. The useful field of view is a measure that reflects decline in visual sensory function, slowed visual processing speed, and impaired visual attention skills. OBJECTIVE To identify whether measures of(More)
The association of CYP2C9 and VKORC1 1173C/T genotype and risk of hemorrhage among African Americans and European Americans is presented. This association was evaluated using Cox proportional hazard regression with adjustment for demographics, comorbidity, and time-varying covariates. Forty-four major and 203 minor hemorrhages occurred over 555 person-years(More)
BACKGROUND We live in a world where information is presented in a time-limited fashion and successful adaptation is dependent on time-limited responses. Slowed visual-processing speed is common among older adults. Its impact on everyday task performance is not clearly understood. OBJECTIVE The goal was to determine whether visual-processing speed, as well(More)
OBJECTIVES To evaluate the relationship between performance-based risk factors and subsequent at-fault motor vehicle collision (MVC) involvement in a cohort of older drivers. DESIGN Prospective cohort study. SETTING Motor Vehicle Administration (MVA) field sites in Maryland. PARTICIPANTS Of the 4,173 older drivers invited to participate in the study,(More)
An overview of the characteristics of traffic crashes among young, middle-aged and older drivers is presented. The results suggest that the youngest and the oldest drivers were more likely to be considered at-fault. With respect to crash characteristics, older drivers were less likely to have crashes involving driver fatigue, during the evening and early(More)
Older drivers have elevated crash rates and are more likely to be injured or die if they have a crash. Medical conditions and medications have been hypothesized as determinants of crash involvement. This population-based case-control study sought to identify medical conditions and medications associated with risk of at-fault crashes among older drivers. A(More)
AIMS The influence of CYP2C9 and VKORC1 on warfarin dose, time to target International Normalized Ratio (INR), time to stabilization, and risk of over-anticoagulation (INR: > 4) was assessed after adjustment for clinical factors, intraindividual variation in environmental factors and unobserved heterogeneity. MATERIALS & METHODS Common CYP2C9 and VKORC1(More)
OBJECTIVES To evaluate the impact of negative pressure wound therapy (NPWT) after severe open fractures on deep infection. DESIGN Prospective randomized study. SETTING Academic level I trauma center. PATIENTS/PARTICIPANTS Fifty-nine patients with 63 severe high-energy open fractures were enrolled in this study, with data available on 58 patients with(More)