Gerald M. Walsh

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Regional blood flows measured in conscious rats by combined Fick and microsphere methods.

Masayuki Tsuchiya, Ronald A. Ferrone, Gerald M. Walsh, Edward David Frohlich
The American journal of physiology
1978

Regional blood flow measurements made by the radioactive microsphere technique were studied in conscious rats. A femoral arterial reference sample blood flow was measured directly, and at the same… (More)

Doxorubicin and C-13 deoxydoxorubicin effects on ryanodine receptor gene expression.

Hervé A. Gambliel, Briant E. Burke, +4 authors Richard D. Olson
Biochemical and biophysical research…
2002

Chronic anthracycline administration to rabbits causes impairment of cardiac contractility and decreased gene expression of the calcium-induced calcium release channel of sarcoplasmic reticulum (SR),… (More)

Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140.

Shanta Bantia, A A Ghate, Sandya L Ananth, Y. Sudhakara Babu, Gillian M. Air, Gerald M. Walsh
Antimicrobial agents and chemotherapy
1998

Influenza neuraminidase (NA) plays an important role in viral replication, and characterization of viruses resistant to NA inhibitors will help elucidate the role of active-site residues. This… (More)

Systemic hemodynamic effects of microspheres in conscious rats.

Masayuki Tsuchiya, Gerald M. Walsh, Edward David Frohlich
The American journal of physiology
1977

The effect of increasing quantities of carbonized microspheres (15 +/- 5 micrometer diam) on systemic hemodynamics was evaluated in 21 Sprague-Dawley, 6 normotensive Wistar-Kyoto (WKY), and 8… (More)

Fluid volumes during onset of spontaneous hypertension in rats.

Nick Trippodo, Gerald M. Walsh, Edward David Frohlich
The American journal of physiology
1978

Body fluid volumes were examined in young spontaneously hypertensive rats (SHR) and in two strains of age-matched normotensive controls to ascertain whether expanded plasma volume (PV) or… (More)

Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.

Pooran Chand, Yarlagadda S. Babu, +10 authors Gerald M. Walsh
Journal of medicinal chemistry
1997

A series of 94 benzoic acid derivatives was synthesized and tested for its ability to inhibit influenza neuraminidase. The enzyme-inhibitor complex structure was determined by X-ray crystallographic… (More)

In vivo and in vitro pharmacologic activity of the purine nucleoside phosphorylase inhibitor BCX-34: the role of GTP and dGTP.

Shanta Bantia, John A. Montgomery, Herbert G. Johnson, Gerald M. Walsh
Immunopharmacology
1996

BCX-34 inhibits RBC PNP in vitro from humans, rats, and mice with IC50S ranging from 5 to 36 nM. BCX-34 also, in the presence but not in the absence of deoxyguanosine, inhibits human CCRF-CEM T-cell… (More)

Selective vasodilation produced by renal denervation in adult spontaneously hypertensive rats.

Angela D. Krueger, Ji Yeon Lee, Philip C. Yang, Stamatis Papaioannou, Gerald M. Walsh
Hypertension
1986

The kidneys of adult male spontaneously hypertensive rats (SHR) were denervated, and systemic and regional blood flows were measured 3 to 5 hours or 5 days after denervation. Arterial pressure was… (More)

Differential blocking effects of prazosin and yohimbine on vasopressor responses to sympathetic nerve stimulation and intravenous norepinephrine in the pithed rat.

Ji Yeon Lee, Gerald M. Walsh, R. D. Heilman, Frederick M. Radzialowski
Research communications in chemical pathology and…
1984

The effects of prazosin and yohimbine on the vasopressor response to sympathetic nerve stimulation, and to i.v. administration of norepinephrine were studied in the pithed rat to ascertain whether… (More)

The metabolism of betahistine in the rat.

L. A. Sternson, Alfonso J. Tobia, Gerald M. Walsh, A W Sternson
Drug metabolism and disposition: the biological…
1974

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