Regional blood flow measurements made by the radioactive microsphere technique were studied in conscious rats. A femoral arterial reference sample blood flow was measured directly, and at the same… (More)
Chronic anthracycline administration to rabbits causes impairment of cardiac contractility and decreased gene expression of the calcium-induced calcium release channel of sarcoplasmic reticulum (SR),… (More)
Influenza neuraminidase (NA) plays an important role in viral replication, and characterization of viruses resistant to NA inhibitors will help elucidate the role of active-site residues. This… (More)
The effect of increasing quantities of carbonized microspheres (15 +/- 5 micrometer diam) on systemic hemodynamics was evaluated in 21 Sprague-Dawley, 6 normotensive Wistar-Kyoto (WKY), and 8… (More)
Body fluid volumes were examined in young spontaneously hypertensive rats (SHR) and in two strains of age-matched normotensive controls to ascertain whether expanded plasma volume (PV) or… (More)
A series of 94 benzoic acid derivatives was synthesized and tested for its ability to inhibit influenza neuraminidase. The enzyme-inhibitor complex structure was determined by X-ray crystallographic… (More)
BCX-34 inhibits RBC PNP in vitro from humans, rats, and mice with IC50S ranging from 5 to 36 nM. BCX-34 also, in the presence but not in the absence of deoxyguanosine, inhibits human CCRF-CEM T-cell… (More)
The kidneys of adult male spontaneously hypertensive rats (SHR) were denervated, and systemic and regional blood flows were measured 3 to 5 hours or 5 days after denervation. Arterial pressure was… (More)
Research communications in chemical pathology and…
1984
The effects of prazosin and yohimbine on the vasopressor response to sympathetic nerve stimulation, and to i.v. administration of norepinephrine were studied in the pithed rat to ascertain whether… (More)